胰腺癌微环境治疗策略的进展与思考

Progress and reflection on the therapeutic strategy of targeting the pancreatic cancer microenvironment

胰腺癌恶性程度较高,明显的间质纤维化及肿瘤异质性是胰腺癌的重要特征,也是胰腺癌患者对目前传统化疗应答欠佳、预后极差的重要原因。因此,寻找有效的治疗策略是提高胰腺癌患者生存率的关键问题。鉴于胰腺癌"间质化"及"异质性"的特性,国内外学者致力于阐明肿瘤微环境在胰腺癌发展过程中的作用机制及寻找有效的微环境靶向治疗策略,以提高胰腺癌患者治疗反应率,实现对于胰腺癌患者精准治疗的目的。本文通过对胰腺癌的微环境研究现状及在精准治疗理念下的靶向胰腺癌微环境的最新进展进行概述,为进一步提高胰腺癌患者的生存率提供新思路。

Pancreatic cancer （PC） is a highly malignant disease. Significant fibrosis and tumor heterogeneity are important characteris- tics of PC that have been attributed to the poor chemotherapeutic response and poor prognosis of patients with PC. Therefore, it is im- perative to develop more effective treatment strategies to improve the survival rate of PC patients. In order to improve the response rates and accuracy of treatment for PC, domestic and foreign scholars have directed their efforts in elucidating the mechanisms of tu- mor microenvironment that mediate PC development to identify more effective treatment strategies targeting this microenvironment. This paper reviews the latest advances and therapeutic strategies for targeting the tumor microenvironment, under the concept of pre- cise treatment, and also provides a new idea for further improving the survival rates of patients with PC.