线粒体DNA变异与肿瘤的相关性研究进展

Research progress on the relationship between mitochondrial DNA variation and tumorigenesis

肿瘤的发生发展是一个较为复杂的生物学过程,其中线粒体在肿瘤细胞代谢过程中扮演重要角色。线粒体DNA(mitochondrial DNA,mtDNA)变异包括点突变、缺失、插入以及拷贝数变异等,这些变异可能参与肿瘤细胞的增殖、生长、侵袭和转移。本文就mtDNA突变、拷贝数改变、mtDNA与核基因(nuclear DNA,nDNA)的比值,以及mtDNA变异与肿瘤发生发展的相关性研究及临床进展进行综述,旨在为深入认识mtDNA变异与肿瘤发生发展的关系并为临床治疗提供更多的参考依据。

The occurrence and development of tumors is a biological process that is extremely complex. In depth research gradually revealed that mitochondria play an important role in the metabolism of tumor cells. The types of mitochondrial DNA （mtDNA） muta- tions identified contain point mutations, deletions, insertions, and copy-number variations. These mutations may be involved in the proliferation, growth, invasion, and metastasis of tumor cells. In this study, mtDNA mutations, copy-number changes, correlation of mtDNA with nuclear DNA, and the progress gained in the development of the relationship between mtDNA mutations and tumorigene- sis are detailed. This review aims to provide additional references to improve the understanding of the relationship between mtDNA mutations and tumor progression.