摘要
结外NK/T细胞淋巴瘤(extranodal natural killer/T-cell lymphoma,ENKTL)是一种与EB病毒(epstein-barr virus,EBV)相关的侵袭性非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL),好发于亚洲和南美洲,其病程进展较快、病死率较高、预后不佳。目前应用的预后模型主要包括国际预后指数(international prognostic index,IPI)、韩国预后指数(Korean prognostic index,KPI)、NK细胞淋巴瘤预后指数(prognostic index of natural killer cell lymphoma,PINK)及包含EBV DNA的NK细胞淋巴瘤预后指数(prognostic index of natural killer cell lymphoma with epstein-barr virus DNA,PINK-E),尚存在一定的局限性。正电子发射断层显像融合计算机断层扫描(positron emission tomography/computed tomography,PET/CT)是一种将解剖结构成像和代谢功能成像相结合的影像技术,具有高敏感性、高特异性的优势,在多种恶性淋巴瘤的诊断、分期、疗效评价和预后评估等方面发挥重要的作用,但其对于ENKTL的预后价值仍存争议。因此,本文针对治疗前、治疗中期和治疗结束后PET/CT对于ENKTL的预后价值进行综述。
Extranodal natural killer/T-cell lymphoma （ENKTL） is an Epstein-Barr virus-associated aggressive non-Hodgkin＇s lymphoma （NHL）. It is prevalent in Asia and South America with an aggressive clinical course and a dismal prognosis. Currently, the prognostic models that are commonly used for ENKTL include the International Prognostic Index （IPI）, Korean Prognostic Index （KPI）, Prognostic In- dex of Natural Killer Cell Lymphoma {PINK）, and Prognostic Index of Natural Killer Cell Lymphoma with Epstein-Barr virus DNA （PINK-E）, all of which have some limitations. Positron emission tomography/computed tomography （PET/CT） is a new imaging technique combin- ing anatomical and functional imaging, with the advantages of high sensitivity and specificity, which is essential for diagnosis, staging, efficacy evaluation, and prognosis prediction of various malignant lymphomas. However, the prognostic value of PET/CT in ENKTL re- mains controversial. Therefore, in this article, we review relevant studies on the prognostic value of pretreatment, interim, and end-of- treatment PET/CT in patients with ENKTL.
作者
赵胜楠
邹立群
Shengnan Zhao;Liqun Zou(West China School of Medicine, Sichuan University, Chengdu 610042, China;The First Department of Oncology, West China Hospital, Sichuan University, Chengdu 610041, China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2018年第6期311-315,共5页
Chinese Journal of Clinical Oncology
