黄斑中心凹脉络膜厚度在糖尿病视网膜病程中作用的研究进展

Recent advances in the effect of sub-foveal choroidal thickness in the course of diabetic retinopathy

糖尿病性视网膜病变（diabetic retinopathy,DR）是全世界范围内失明的主要原因。既往基于组织学、血管造影及多普勒技术的研究发现DR除了引起视网膜病变外,同时发现脉络膜缺血和血流灌注异常等。黄斑区的营养仅由脉络膜提供,DR患者中黄斑区脉络膜毛细血管的损害对中心凹视网膜功能的影响更为显著,致黄斑中心凹下脉络膜厚度（sub-foveal choroidal thickness,SFCT）发生改变,因此对SFCT的观察对于追踪DR病程发展有较重要的意义。光学相干断层扫描（optical coherence tomography,OCT）的深度增强成像技术（enhanced depth imaging-technique,EDI）能较准确的测量SFCT,对研究DR病程中SFCT的改变提供了有力保障。在此,就SFCT的改变在DR病程发展中的作用的研究进展行如下综述。

Diabetic retinopathy is a leading contributor to the burden of all-cause blindness worldwide. In addition to retinal changes,the choroidal ischemia and vascular perfusion abnormalities are common in patients with DR. The first studies concerning this vascular structure were based on histologic,indocyanine angiography and laser doppler flowmetry techniques. Choroidal vasculature is the only source of macular oxygen and nutrient supply. In the patients with DR,the damage of choroidal capillaries in the macular region has more meaningful impact on the foveal retinal function,and which leads to change in SFCT. Therefore,the research of SFCT has great meaning for tracing the course of DR. Depth enhanced imaging of optical coherence tomography can accurately measure SFCT,which provides a powerful guarantee for studying the change of SFCT in the course of DR. The research of SFCT in the course of DR in recent years are reviewed.