基因治疗骨关节病的研究进展

Research Progress of Gene Therapy on Osteoarthrosis

骨关节病是常见的以软骨损伤为特征的关节退行性疾病,目前的治疗方法较多,但大多实施困难且效果不佳。颞下颌关节骨关节病作为一种常见的口腔颌面疾病,其修复与治疗对临床和科研工作者具有挑战性。基因治疗是近年发展起来的一项新兴诊疗技术,因其对软骨生物学性能的潜在修复力而逐渐引起人们重视。它主要涉及到靶细胞、目的基因、载体这三方面的问题,本文就此作一综述。

Osteoarthrosis is a common degenerative joint disease,which is characterized by cartilage injury.Temporomandibular joint osteoarthrosis is a common oral and maxillofacial disease,its repair and treatment are quite challenging job to clinical and scientific researchers.It is a lot of treatment of this disease,but the effect is not satisfactory.Gene therapy is a new treatment technology developed in recent years,which involves the target cell,gene,carrier and so on.This article summarized the current literature on gene therapy of osteoarthrosis.