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铜绿假单胞菌对不同抗菌药物的耐药性与碳青霉烯类抗菌药物使用的相关因素分析 被引量:7

Analysis on Correlation Factors Between Antimicrobials Resistance of Pseudomonas Aeruginosa and Usage of Carbapenem Antibiotics
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摘要 目的:分析铜绿假单胞菌对不同抗菌药物的耐药性与碳青霉烯类抗菌药物使用的相关因素。方法:抽取2015年7月—2017年6月间收治的住院患者送检标本检验结果资料,统计其铜绿假单胞菌对不同抗菌药物的耐药率,以及其对碳青霉烯类抗菌药物的耐药率及碳青霉烯类抗菌药物的使用量、DDDs,分析两者间的相关性。结果:2年间碳青霉烯类抗菌药物的使用量由2015年第3季度DDDs 421.88增至2017年第2季度DDDs788.75,铜绿假单胞菌对碳青霉烯类的耐药率也逐年增长,而对美罗培南的耐药率由14.36%增至34.70%,对亚胺培南的耐药率由19.88%增至41.18%;显示铜绿假单胞菌对美罗培南、亚胺培南的耐药率与美罗培南、碳青霉烯类抗菌药物的使用量之间具有相关性。结论:各碳青霉烯类抗菌药物的使用量与铜绿假单胞菌对美罗培南、亚胺培南的耐药率呈正相关。 Objective: To analyze the correlation factors between antimicrobials resistance ofPseudomonas aerugi- nosa and usage of carbapenem antibiotics. Methods: Samples test results data of from during July 2015 to June 2017 hospitalized patients admitted were extracted. The Pseudomonas aeruginosa to different antimicrobial resistance as well as for the carbapenems antibiotics resistance and usage of antimicrobial and DDDs were counted, the correlation be- tween the two were analyzed. In the two years, the usage of carbapenem antibacterial drugs increased from DDDs 421.88 in the third quarter of 2015 to DDDs 788.75 in the second quarter of 2017. The drug resistance rate of Pseudorno- nas aeruginosa was also increasing year by year. However, the drug resistance rate was increased from 14.36% to 34.70%, and the drug resistance rate was increased from 19.88% to 41.18%. There was a correlation between the resis- tance rate of Pseudomonas aeruginosa will meropenem and imipenena and the usage of antimicrobial agents in meropen- em and carbapenem. Conclusion: The usage of the antibacterial agents of carbapenem and Pseudomonas aeruginosa were positively correlated with the drug resistance rate of meropenem and imipenem.
作者 万永艳 WAN Yong-yan(Department of Pharmacy, Liuzhou Hospital of TCM, Liuzhou Guangxi 545001, China)
出处 《抗感染药学》 2018年第2期203-206,共4页 Anti-infection Pharmacy
关键词 碳青霉烯 抗菌药物 铜绿假单胞菌 耐药率 carbapenems antibiotics antibiotics Pseudomonas aeruginosa resistance rate
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