基于因子分析和Logistic回归分析的溃疡性结肠炎证候研究

Study on Syndrome of Ulcerative Colitis Based on Factor Analysis and Logistic Regression Analysis

目的：探讨因子分析和Logistic回归分析在溃疡性结肠炎中医证候研究中的应用,为溃疡性结肠炎证候分类及制定诊断标准提供一定的科学依据。方法：采用自拟《溃疡性结肠炎的中医证候流行病学调查表》收集溃疡性结肠炎患者618例,并行因子分析和Logistic回归分析。结果：应用因子分析的方法,得出溃疡性结肠炎证候特征为活动期大肠湿热证、寒湿内盛证和肝郁脾虚证,缓解期脾胃虚弱证、脾肾阳虚证、肝郁脾虚证、阴虚肠燥证、血瘀肠络证;运用多元Logistic回归分析,得出溃疡性结肠炎证候的症状量化指标。结论：因子分析和Logistic回归分析结合的多元统计方法可用于溃疡性结肠炎中医证候分类及量化诊断研究,为该病的证候诊断标准研究提供了一种新的方法。

Objective： To explore the application of factor analysis and Logistic regression analysis in the study of TCM syndromes of ulcerative colitis and provide a scientific basis for the classification of ulcerative colitis syndrome and the development of diagnostic criteria. Methods： By using self-made ＂ulcerative colitis TCM syndrome epidemiology questionnaire＂,618 cases of ulcerative colitis were collected and analyzed by factor analysis and cluster analysis method. Results： By using the method of factor analysis,the basic TCM syndromes of the active ulcerative colitis were obtained as damp-heat syndrome,the cold-dampness syndrome and liver stagnation and spleen deficiency. The basic TCM syndromes of ulcerative colitis in remission are obtained as the spleen and stomach qi deficiency,yang deficiency of spleen and kidney,liver stagnation and spleen deficiency,yin deficiency and intestinal dryness and intestinal collaterals and blood stasis. By using multiple Logistic regression analysis,the symptom of ulcerative colitis was quantified. Conclusion： Multivariate statistical methods of factor analysis and Logistic regression analysis can be used for the classification and quantitative diagnosis of ulcerative colitis,which also provides a new method to study the syndrome diagnosis standard of this disease.