摘要
目的:观察隔药灸脐法、药物贴脐法、艾条灸脐法对寒凝血瘀型痛经模型大鼠行为学的影响,并比较其疗效差异。方法:将50只雌性Wistar大鼠随机分为空白组、模型组、隔药灸脐组、药物贴脐组、艾条灸脐组5组,每组10只;除空白组外,各组均造寒凝血瘀型痛经模型;造模成功后,空白组与模型组不给予任何治疗,隔药灸脐组、药物贴脐组、艾条灸脐组分别采用隔药灸脐法、药物贴脐法、艾条灸脐法进行治疗;观察并记录各组大鼠治疗前后症状、一般情况的改变,以及治疗后30 min内的扭体潜伏时间及扭体次数,比较各组疗效差异。结果:隔药灸脐法、药物贴脐法、艾条灸脐法均可改善寒凝血瘀型痛经模型大鼠的症状,隔药灸脐法疗效最明显;在改善每日饮水量和体质量增长率方面,隔药灸脐法优于艾条灸脐法(P〈0.01),艾条灸脐法优于药物贴脐法(P〈0.01);在改善每日进食量方面,隔药灸脐法优于药物贴脐法和艾条灸脐法(P〈0.01),后两者疗效无差异。隔药灸脐法、药物贴脐法、艾条灸脐法均可延长扭体潜伏期、降低扭体分数、减少扭体次数(P〈0.01);在降低扭体分数、减少扭体次数方面,隔药灸脐法优于药物贴脐法和艾条灸脐法(P〈0.01),后两者疗效无差异。结论:脐疗可以减轻寒凝血瘀型痛经模型大鼠的症状,改善饮水量、进食量、体质量增长率等一般情况,且具有明显的镇痛作用。其中隔药灸脐法疗效优于艾条灸脐法,艾条灸脐法疗效优于药物贴脐法。
Objective: To observe the effect of fumigating the navel,drug stick at the navel and moxibustion on the navel to behavior model of cold coagulation and blood stasis dysmenorrhea rats and compare the differences between each group in efficacy.Methods: Fifty female Wistar rats were randomly divided into 5 groups: group A(normal group),group B(model group),group C(group of herb-partition moxibustion on the navel),group D(group of drug covering navel therapy) and group E(group of navel therapy with moxa stick moxibustion). Rats in the navel therapy groups and group B were constructed as cold coagulation and blood stasis type of primary dysmenorrhea model. We gave each group the corresponding treatment from the sixth day of the start of modeling,once a day,for 5 times in total. After treatment,we observed and recorded the symptoms and writhing of rats and compared the differences between each group. Results: Three navel therapy groups can improve the symptoms and general situation of cold coagulation and blood stasis dysmenorrhea model rats. In the improvement of daily water intake and body weight growth rate,group C was better than group E(P〈 0. 01) and group E was better than group D(P〈 0. 01). In the improvement of the daily food intake,group C was better than group D and E(P〈 0. 01). There was no difference showed in efficacy between group D and E. Three navel therapy groups can prolong the writhing latency and reduce writhing scores and writhing(P〈 0. 01). As for reducing writhing scores and writhing times,group C was better than group D and E(P〈 0. 01). There was no difference showed in efficacy between group D and E. Conclusion: The navel therapy groups could improve the general situation and pain symptoms of cold coagulation and blood stasis type of PD model rats. The advantages of herb-partition moxibustion on the navel are more obvious than the other two navel therapies.
作者
李姝婧
张晓宁
孙铭声
李昭凤
高树中
马玉侠
LI Shujing;ZHANG Xiaoning;SUN Mingsheng;LI Zhaofeng;GAO Shuzhong;MA Yuxia(Shandong University of Traditional Chinese Medicine, Jinan 250014, Shandong, China;Institute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences, Beijing 6100700, China;Chengdu University of Traditional Chinese Medicine, Chengdu 610075, Sichuan, China)
出处
《辽宁中医杂志》
CAS
2018年第2期390-393,I0002,共5页
Liaoning Journal of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81373721)
关键词
脐疗
寒凝血瘀
痛经
大鼠
行为学
隔药灸脐
navel therapy
congealing cold and blood stasis
dysmenorrhea
rat
behavior
herb - partition moxibustion on navel