六味地黄丸配合阿仑膦酸钠治疗肝肾阴虚型绝经后骨质疏松症的临床研究

Effect of Liuwei Dihuang Pills Combined with Alendronate in Treatment of Liver-kidney-yin Deficiency Type of Postmenopausal Osteoporosis

目的观察六味地黄丸结合阿仑膦酸钠治疗肝肾阴虚型绝经后骨质疏松症的疗效。方法选取60例肝肾阴虚型绝经后骨质疏松症患者作为研究对象,分为观察组和对照组。观察组予以六味地黄丸结合阿仑膦酸钠治疗,对照组予以阿仑膦酸钠治疗,24周后,分别比较两组治疗前后视觉模拟评分(VAS)、骨密度及疲劳量表(FS-14)评分。结果两组治疗前后疼痛程度、骨密度和疲劳值均逐渐改善,差异均有统计学意义(P<0.05),观察组疲劳值改善显著高于对照组(P<0.05)。结论六味地黄丸结合阿仑膦酸钠治疗肝肾阴虚型绝经后骨质疏松症可更有效减轻疼痛、缓解疲劳,临床综合效果更好。

Objective To observe the curative effect ofLiuwei Dihuang pills combined with alendronate in treatment of liver-kidney-yin deficiency type ofpostmenopausal osteoporosis. Methods 60 cases of patients with liver-kidney-yin deficiency type of osteoporosis were divided into observation group and control group. Observation group was given Liuwei Dihuang pills combined with alendronate sodium, while control group was given alendronate sodium. After 24 weeks, visual analogue scale （VAS）, bone mineral density and fatigue scale （FS-14） scores of the two groups before and after treatment were compared. Results Before and after treatment, the degree of pain, bone mineral density and the improvement of fatigue in both groups gradually improved, the difference was statistically significant （P〈0.05）.The improvement of fatigue in observation group was significantly higher than that in control group （P〈0.05）. Conclusion Liuwei Dihuang pills combined with alendronate is effective in relieving pain and fatigue in treatment of liver-kidney-yin deficiency type ofpostmenopausal osteoporosis, and the clinical comprehensive effect is better.