急性心肌梗死患者血清内脏脂肪素与基质金属蛋白酶的相关性研究

Relationship between serum levels of visfatin,matrix metalloproteinase in acute myocardial infarction patients

目的探讨急性心肌梗死(AMI)患者血清内脏脂肪素及基质金属蛋白酶(MMP)-2、MMP-9水平的变化。方法选择2015年3月~2016年3月淄博市中心医院心内科住院的首次AMI患者75例(AMI组),另选择年龄、性别相匹配的健康体检者60例(对照组),采用定量夹心酶联免疫吸附法检测血清内脏脂肪素、MMP-2、MMP-9及其他生化指标。对血清内脏脂肪素与MMP-2、MMP-9、高敏C反应蛋白及其他临床生化指标进行Pearson相关性分析。结果 AMI组LDL-C、内脏脂肪素、MMP-2、MMP-9及高敏C反应蛋白水平明显高于对照组[(3.45±0.87)mmol/L vs(2.89±0.65)mmol/L,(8.06±2.21)μg/L vs(5.53±1.23)μg/L,(150.18±74.58)μg/L vs(64.60±25.86)μg/L,(478.77±165.46)μg/L vs(263.54±99.35)μg/L,(12.07±2.50)mg/L vs(4.62±1.82)mg/L,P<0.01]。AMI组血清内脏脂肪素与MMP-2、MMP-9、高敏C反应蛋白呈正相关(P<0.01)。结论急性心肌梗死患者血清内脏脂肪素水平显著升高,表明血清内脏脂肪素与动脉粥样硬化斑块的破裂密切相关。

Objective To study the relationship between serum levels of visfatin,MMP-2 and MMP-9 in AMI patients.Methods Seventy-five AMI patients served as an AMI group and 60 age-and gender-matched subjects undergoing physical examination served as a control group in this study.Their serum levels of visfatin,MMP-2 and MMP-9 were measured and other biochemical parameters were recorded by ELISA.The relationship of serum levels of visfatin with those of MMP-2,MMP-9,hs-CRP and biochemical parameters was analyzed by Pearson correlation analysis.Results The serum levels of LDL-C,visfatin,MMP-2 MMP-9 and hs-CRP were significantly higher in AMI group than in control group（3.45±0.87 mmol/L vs 2.89±0.65 mmol/L,8.06±2.21μg/L vs 5.53±1.23μg/L,150.18±74.58μg/L vs 64.60±25.86μg/L,478.77±165.46μg/L vs 263.54±99.35μg/L,12.07±2.50 mg/L vs 4.62±1.82 mg/L,P〈0.01）.The serum levels of visfatin were positively related with those of MMP-2,MMP-9 and hs-CRP.ConclusionThe serum visfatin level is significantly higher in AMI patients,indicating that the serum visfatin level is closely related with the rupture of atherosclerotic plaques and can thus be used as an important marker of unstable atherosclerotic plaques and the rupture of atherosclerotic plaques.