针灸治疗脑卒中抑郁症患者的疗效及对患者神经功能的影响

Study on Efficacy of Acupuncture in Treating Stroke Patients with Depression and Effects on Neurological Function

目的:探讨针灸治疗脑卒中抑郁症患者的疗效及对患者神经功能的影响。方法:选取2015年6月至2016年12月天津中医药大学第一附属医院收治的脑卒中抑郁症患者134例,按照随机表法分为观察组67例与对照组67例。对照组口服米氮平片,观察组在对照组基础上结合针灸治疗。2组疗程均为8周。比较2组治疗疗效,治疗前后NIHSS评分、HAMD评分、Balthel指数评分及血浆Cor和神经肽Y水变化。结果 :观察组治疗有效率(95.52%)高于对照组(76.12%),差异有统计学意义(P<0.05);2组治疗后NIHSS评分和HAMD评分降低,差异有统计学意义(P<0.05);观察组治疗后NIHSS评分和HAMD评分低于对照组(P<0.05);2组治疗后Balthel指数评分增加,差异有统计学意义(P<0.05);观察组治疗后Balthel指数评分高于对照组(P<0.05);2组治疗后血浆Cor降低而神经肽Y水平增加,差异有统计学意义(P<0.05);观察组治疗后血浆Cor高于对照组,而神经肽Y水平低于对照组(P<0.05)。结论 :针灸治疗脑卒中抑郁症患者疗效明显,且可改善患者神经功能,具有重要研究意义。

Objective： To investigate the efficacy of acupuncture treatment on stroke patients with depression and effects on neurological function. Methods： A total of 134 stroke patients with depression from First Hospital Affiliated to Tianjin Medical University from June 2015 to December 2016 were selected. They were randomly divided into observation group（ n = 67） and control group（ n = 67）. The control group was treated with Mirtazapine Tablets,while the observation group was treated with acupuncture combined with the control group. The two groups were treated for 8 weeks. The therapeutic effects were compared between the two groups before and after treatment. The NIHSS score,HAMD score,Balthel index score and the changes of plasma Cor and neuropeptide Y were observed before and after treatment. Results： The total efficiency of the observation group（ 95. 52 %） was higher than the control group（ 76. 12 %）（ χ2= 10. 364,P〈0. 05）; the NIHSS score and HAMD score decreased in two groups after treatment,and there were significant differences（ observation group,t = 17. 890,21. 575,control group t = 10. 243 、9. 808,P〈0. 05）; NIHSS score and HAMD score in the observation group after treatment were lower than the control group（ t = 9. 557,11.939,P〈0. 05）; Balthel score of the two groups after treatment increased,and there were significant differences（ observation group t = 24. 793,control group t = 12. 827,P〈0. 05）; Balthel score of the observation group after treatment was higher than the control group（ t = 11. 333,P〈0. 05）; plasma Cor levels decreased,and neuropeptide Y creased in two groups after treatment with statistical difference（ observation group t = 10. 089,23. 183,control group t = 5. 388,17. 019,P〈0. 05）; the plasma Cor of observation group after treatment was higher than the control group,while neuropeptide Y was lower than the control group（ t =5. 388,7. 364,P〈0. 05）. Conclusion： Acupuncture in the treatment of stroke patients with depression has significant curative effects,and can improve the neurological function of patients,with important research significance.