摘要
目的 通过对合肥市城区居民甲状腺疾病患者与健康人群尿碘水平的对比分析,探讨尿碘水平与甲状腺功能的关系。方法 采用前瞻性研究,在2015年3月至2017年1月,以在安徽医科大学第三附属医院内分泌科住院及门诊就诊的甲状腺疾病患者238例作为病例组,其中包括Graves病组(GD组,116例)、慢性淋巴细胞性甲状腺炎组(HT组,79例)和甲状腺结节组(43例),同时选择相同时期进行健康体检的合肥市城区无甲状腺疾病居民568例作为对照组。采用砷铈催化分光光度法测定尿碘、化学发光免疫分析技术测定血清促甲状腺激素(TSH)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)及甲状腺过氧化物酶抗体(TPOAb)、甲状腺球蛋白抗体(TgAb),病例组和对照组均进行甲状腺B超检查。结果 GD组、HT组、甲状腺结节组和对照组尿碘中位数分别为326.83、361.49、235.26、195.63 μg/L,组间尿碘中位数比较差异有统计学意义(H = 20.13,P 〈 0.05)。GD组和HT组尿碘中位数均显著高于对照组(Z = 5.395、6.269,P均 〈 0.05);HT组与甲状腺结节组比较差异有统计学意义(Z = 3.852,P 〈 0.05)。GD组TSH、FT3、FT4、TPOAb、TgAb与对照组比较差异有统计学意义(P均 〈 0.05);HT组和甲状腺结节组TPOAb、TgAb与对照组比较有统计学意义(P 〈 0.05);4组人群的尿碘水平与TSH、FT3、FT4、TPOAb、TgAb间均无相关性(P均 〉 0.05)。结论 依据正常人群尿碘水平,合肥市城区属于碘适量地区。合肥市城区居民尿碘水平与甲状腺功能未见相关性。
Objective To investigate the relationship between urinary iodine level and prevalence of thyroid disease by comparing the levels of urinary iodine in patients with thyroid disease and healthy people in Hefei urban residents. Methods A prospective study was used in the study. A total of 238 patients with thyroid disease were enrolled in the Third Affiliated Hospital of Anhui Medical University from March 2015 to January 2017, and these patients were divided into three groups: Graves's disease (GD) group (n = 116), chronic lymphocyticthyroiditis (HT) group (n = 79) and thyroid nodule group (n = 43), 568 cases of Hefei urban residents without thyroid disease were selected as control group Urinary iodine was measured by arsenic-cerium catalyzed spectrophotometry. Thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) were measured by chemiluminescence immunoassay. The thyroid was examined through B ultrasonography in both the case group and the control group. Results The median urinary iodine concentrations(MUIC) of GD group, HT group, thyroid nodule group and control group were 326.83, 361.49, 235.26, and 195.63 μg/L, there were significant differences in the MUIC between the 4 groups (H = 20.13, P 〈 0.05). The MUIC of GD group and HT group were higher than that of control group (Z = 5.395, 6.269, P 〈 0.05). The MUIC was significantly different between the HT group and the thyroid nodule group (Z = 3.852, P 〈 0.05). There were significant differences in TSH, FT3, FT4, TPOAb, TgAb between the GD group and the control group (P 〈 0.05); the TPOAb and TgAb in the HT group and thyroid nodule group were statistically significantly different compared with those of control group (P 〈 0.05). There was no correlation between the level of urinary iodine level and FT3, FT4, TSH, TPOAb and TgAb in the 4 groups (P 〉 0.05). Conclusions According to the urinary iodine level in the normal population, the Hefei urban area belongs to the area of appropriate iodine. There was no corrolation between urinary iodine level and thyroid function in urban residents of Hefei.
作者
陈赟
马维青
陶存武
Chen Yun;Ma Weiqing;Tao Cunwu(Department of Endocrinology, the Third Affiliated Hospital of Anhui Medical University, Hefei 230061, China (Chen Y, Ma WQ;Department of Nuclear Medicine, the Third Affiliated Hospital of Anhui Medical University, Hefei 230061, China (Tao CW)
出处
《中华地方病学杂志》
CAS
CSCD
北大核心
2018年第4期334-337,共4页
Chinese Journal of Endemiology
基金
合肥市2016年度科技攻关计划(2016-74)
关键词
尿
碘
甲状腺疾病
Urine
Iodine
Thyroid disease