摘要
目的探讨红花黄色素对高龄ST段抬高型心肌梗死(STEMI)患者急诊PCI术后急性、亚急性支架内血栓形成(IST)的防治作用。方法以2009年4月至2017年3月期间符合条件的786例STEMI患者为研究对象,随机分为研究组388例和对照组398例,研究组在对照组常规治疗的基础上给予红花黄色素治疗。所有患者均于术前、急诊PCI术后1天、3天、10天、30天抽取空腹静脉血检测血小板活化因子(PAF)。监测PCI术后30天内IST事件和出血事件。结果与对照组相比,研究组术后1天、3天、10天的血清PAF水平均显著降低。对照组有15例(3.9%)发生急性、亚急性IST,研究组有5例(1.3%)发生急性、亚急性IST,两组之间存在显著差异(χ^2=4.948,P=0.026)。研究组有5例(1.3%)发生出血事件,对照组有7例(1.8%)发生出血事件,两组之间无显著差异(χ^2=0.522,P=0.770)。结论红花黄色素能够预防高龄STEMI患者急诊PCI术后急性和亚急性IST的发生,并且不增加出血事件,值得在临床中进一步推广应用。
Aim To investigate the preventive and therapeutic effects of safflower yellow on acute and subacute in-stent thrombosis( IST) after emergency PCI in advanced age patients with ST-elevated myocardial infarction( STEMI).Methods A total of 786 STEMI patients were enrolled from April 2009 to March 2017,and randomly divided into the study group( 388 cases) and the control group( 398 cases),the study group was treated with safflower yellow on the basis of routine treatment in the control group. Fasting venous blood were taken to detect platelet activating factor( PAF) in all patients at 1,3,10 and 30 days after PCI. IST events and hemorrhagic events were monitored within 30 days after PCI.Results Compared with the control group,the study group had a significantly decreased level of the serum PAF at 1,3 and 10 days after PCI. 15 cases( 3.9%) occurred acute and subacute IST in the control group and 5 cases( 1.3%) occurred acute and subacute IST in the study group,there was significant difference in the incidence of IST between the two groups( χ^2= 4.948,P = 0.026). Bleeding events occurred in 5 cases( 1.3%) of the study group and 7 cases( 1.8%) of the control group,there was no significant difference in the incidence of bleeding events between the two groups( χ^2=0.522,P = 0.770). Conclusion Safflower yellow can prevent the occurrence of acute and subacute IST in advanced age patients with STEMI after emergency PCI and does not significantly increase the bleeding event. Safflower yellow is worth applying in clinical practice furtherly.
作者
杨静
马文君
刘长青
刘晓霞
YANG Jing;MA Wen-Jun;LIU Chang-Qing;LIU Xiao-Xia(Depatment of Geriatric;3. Department of Cardiology, Tangshan Worker's Hospital, Tangshan, Hebei 063000, Chin;2. Department of Cardiology, Fuwai Cardiovascular Hospital, Beijing 100037, China)
出处
《中国动脉硬化杂志》
CAS
2018年第3期291-294,共4页
Chinese Journal of Arteriosclerosis
关键词
红花黄色素
高龄
急性心肌梗死
支架内血栓形成
Safflower yellow
Advanced age
Acute myocardial infarction
In-stent thrombosis