基于历代中医文献的细辛证治规律与常用剂量探索

Research on Rule of Syndrome-treatment and Common Dosage of Asari Radix et Rhizoma Based on Traditional Chinese Medicine Ancient Literature

目的：研究细辛的主治病证、配伍特点和常用剂量,为临床合理使用细辛提供参考。方法：收集历代中医方剂文献中含细辛的方剂,采用SQL Server 2008构建细辛方数据库,采用SPSS 19.0统计频数、均值等参数,运用SQL Server 2008开展数据的关联分析。从内服和外用2个方面分析细辛方的主治病证范围、配伍特点及常用剂量。结果：共采集到4 489首含细辛的方剂;从内服和外用2个方面分别挖掘出了细辛方主治频数最高的前15个病证、配伍频数最高的前10味中药;确定细辛内服汤剂的常用剂量范围为1.85-13.75 g。结论：细辛的主治病证与药物配伍存在着明显的关联性;从汉朝至南北朝到清代呈现出依次递减的规律;细辛临床常用剂量以1.85-13.75 g为宜,针对不同的病证,可以配伍不同的方药、使用不同的剂量,不应受＂细辛不过钱＂的观点所束缚。

Objective： To guide the clinical treatment for rational use of Asari Radix et Rhizoma by studying on its indications,formulae compatibility and usual dosage based on traditional Chinese medicine（TCM）ancient literature. Method： This paper collected ancient literatures of TCM prescription containing Asari Radix et Rhizoma,and constructed its database by SQL Server 2008. From oral and external use of Asari Radix et Rhizoma,this paper analyzed its indications, usual dosage and rules of formulae compatibility by means of statistical frequency and mean in SPSS 19. 0 and SQL Server 2008 carrying out correlation analysis. Result： This study collected 4 489 formulae that containing Asari Radix et Rhizoma from ancient book of TCM. From the two aspects of oral and external use of Asari Radix et Rhizoma,this paper dug out the top 15 symptoms of indications and the top 10 herbs of formulae compatibility. The usual oral dosage of Asari Radix et Rhizoma was 1. 85-13. 75 g.Conclusion： There is a clear correlation between the indications and formulae compatibility of Asari Radix et Rhizoma. From the Han dynasty to Qin dynasty,the dosage of Asari Radix et Rhizoma decreased successively.The common dosage of Asari Radix et Rhizoma should be 1. 85-13. 75 g. According to different indications,Asari Radix et Rhizoma should be compatible with different herbs and different dosages,we should not be affected by the opinion of ‘the dosage of Asari Radix et Rhizoma should not exceed one Qian＇.