二硫键连接的纳米粒子用于细胞内药物递释的研究进展

Recent Progress of Disulfide Bond Linked Nanoparticles for Intracellular Drug Delivery

传统刺激响应型纳米粒子虽能实现智能敏感性的药物释放,但药物释放行为在细胞内外没有明显差异,药物多在细胞外就已经释放。基于二硫键连接的纳米粒子可以利用肿瘤细胞内外谷胱甘肽的巨大浓度差异来实现细胞内快速释放,提高药物生物利用度。本文主要从二硫键的3种释放功能:粒子解体、粒子稳定性变化、多孔材料开关等方面来介绍不同二硫键连接的纳米粒子的应用优势,综述此类纳米粒子的研究进展和发展方向,并总结细胞内各部分还原环境和阐述二硫键连接的纳米粒子的设计策略。

Although stimuli-responsive nanoparticles （NPs） have gained a great interest for intelligent drug delivery, they cannot distinguish between intracellular and extracellular environment. Most of the drugs have been released extracellularly, resulting in low bioavailability and high side effects. Thus it is of great intrest to design disulfide bond linked NPs related to high glutathione （GSH） level in tumor intracellular microenvironment for intracellular drug delivery. In this review, we focus on the recent exciting advances in designing disulfide bond linked nanoparticles. We mainly introduce the three release mechanisms from disulfide bond linked nanoprticles： particle disassembly, the change of particle stability and ＂nanogate＂ of the mesoporous materials. The cellular GSH environment and design strategy of disulfide bond linkage are also described.