探讨快速评价法在检索雷公藤制剂肾毒性研究中的应用

Application of evidence-based rapid review in studying nephrotoxicity of Tripterygium wilfordii preparation

为了探讨快速评价法在中药肾毒性研究中的可行性,采用4种检索策略检索雷公藤制剂肾毒性的相关研究,一是不限定任何检索词,即采用传统的系统评价检索方法;二是将雷公藤制剂的相关检索词限定为＂CFDA批准上市的所有包含雷公藤成分的中成药＂;三是将肾毒性的相关检索词限定为＂前期系统评价研究文献筛选过程中发现的报道最多的与肾毒性相关的词汇＂;四是同时限定雷公藤制剂和肾毒性相关检索词。最后,将后3种检索方法的结果与第1种检索方法的检索结果对比。从检索到的总文献量上来看,不限制检索词的方法检索到的总文献量最多,分别限制雷公藤制剂和肾毒性检索词检索到的文献总量相对减少,同时限定者2种检索词检索到的文献总量最少。从符合纳入标准的文献量上来看,限制雷公藤制剂的方法纳入的文献数量最多。从纳入的文献类型上来看,同时限定雷公藤制剂和肾毒性相关检索词与不限定检索词的检索结果相比,符合度较高。快速评价方法在中药肾毒性的研究中应用是可行的。

To investigate the feasibility of applying the evidence-based rapid review in studying the nephrotoxicity of Tripterygium wilfordii preparation. We used four methods in relevant studies on the nephrotoxicity of T. wilfordii preparation. The first method had no limitation on any search terms,which was a traditional approach to retrieve systematic reviews. The second method limited the relevant search terms of T. wilfordii preparation to ＂ all of CHMs containing T. wilfordii preparation approved by CFDA＂. The third method was to limit the relevant retrieval terms of nephrotoxicity as the ＂ most frequently reported terms related to nephrotoxicity found in the study literature screening process in the early stage of systematic review＂. The fourth method was to limit the search terms relating to both T. wilfordii preparation and nephrotoxicity. Finally,the results of the last three search methods were compared with those of the first search method,and the feasibility of the rapid review method in the study for the nephrotoxicity of CHM was discussed. For the total number of literatures searched,the fourth method had the smallest number of literatures. For the number of articles in line with the inclusion criteria,the second method had the largest number of eligible literatures. For the type of literatures included,the forth method had a higher coincidence degree. The forth method was the best one,because it was not only consistent with the results,but also could minimize the workload. Rapid review is feasible in the study of nephrotoxicity of T. wilfordii.