支气管哮喘急性发作期血氧饱和度水平与磷脂酶Cε的关系

Relationship between PLCε and Oxygen Saturation in Patients during the Acute Episode of Asthma

目的:探讨磷脂酶Cε(PLCε)与支气管哮喘患者急性发作期血氧饱和度(SaO_2)的关系。方法:243例支气管哮喘患者,根据SaO_2水平将患者分成3组,分别为SaO_2>95%组、91%≤SaO_2≤95%组和SaO_2<91%组,比较3组患者一般临床资料、磷脂酶Cε(PLCε)水平、趋化因子Ccl2、Cxcl2及炎症因子IL-4、IL-5和IL-13水平,并多因素回归分析PLCε水平与SaO_2及第1秒用力呼气容积(FEV_1)的相关性。结果:3组患者年龄间差异有统计学意义(P<0.05);SaO_2<90%组血清PLCε水平最高(均P<0.05),且91%≤SaO_2≤95%组高于SaO_2>95%组(P<0.05),SaO_2<90%组Ccl2、Cxcl2、IL-4、IL-5和IL-13表达水平最高(均P<0.05),且91%≤SaO_2≤95%显著高于SaO_2>95%组(P<0.05);多因素回归分析患者血清PLCε水平与SaO_2呈显著负相关,与FEV_1水平呈正相关(均P<0.05)。结论:支气管哮喘急性发作期SaO_2与血清PLCε呈负相关,PLCε可能通过影响支气管哮喘患者气道炎症反应而影响患者SaO_2及肺通气功能。

Objective： To investigate the relationship between PLCε and oxygen saturation in patients with acute episode of asthma. Methods： According to the oxygen saturation level,243 cases of bronchial asthma were divided into 3 groups（95% group,91%-95% group and 90% group）. The clinical data,PLCε,chemokines Ccl2 and Cxcl2,and inflammatory factors IL-4,IL-5 and IL-13 were compared among three groups. The correlation between PLCε level with oxygen saturation and FEV1 was analyzed. Results： There was significant difference in age among three groups（P〈0.05）. The expression level of PLCε in 90% group was highest（P〈0.05）,and that in 91%-95% group was significantly higher than in 95% group（P〈0.05）. The expression levels of Ccl2,Cxcl2,IL-4,IL-5 and IL-13 in 90% group were highest（P〈0.05）. The expression levels of Ccl2,Cxcl2,IL-4,IL-5 and IL-13 in 91%-95% group were significantly higher than those in 95% group（P〈0.05）. The PLCε was negatively correlated with the levels of blood oxygen saturation and positively with the levels of FEV1. Conclusion： There was a significant negative correlation between the oxygen saturation and PLCε in acute bronchial asthma. PLCε may influence the blood oxygen saturation and pulmonary ventilation function probally by infulencing the inflammation of respiratory tract in patients with bronchial asthma.