丹参多酚酸盐联合康复教育对冠心病患者血浆同型半胱氨酸、血清转化生长因子-β_1的表达及生活质量的影响

Effect of Salvianolate Combined with Rehabilitation Education on the Expression of Plasma Homocysteine,Serum Transforming Growth Factor-β_1 and Quality of Life in Patients with Coronary Heart Disease

目的探讨丹参多酚酸盐联合康复教育对冠状动脉粥样硬化性心脏病(简称冠心病)患者血浆同型半胱氨酸(Hcy)、血清转化生长因子-β1(TGF-β1)的表达及生活质量的影响。方法选择2015年12月至2017年1月收治的冠心病患者130例,按照随机数字表法分为观察组和对照组,各65例。两组患者均继续治疗相关基础疾病,静脉滴注丹参多酚酸盐注射液200 mg,每日1次,连续1个月。结果与治疗前比较,治疗后两组患者总运动时间、ST段压低1 mm时间均明显增加,最大运动耐量明显增大,且观察组改善更明显(P<0.05);治疗后,两组患者Hcy及TGF-β1、B型脑钠肽(BNP)、γ-干扰素(IFN-γ)水平均明显降低(P<0.05),但组间差异不显著(P>0.05);治疗后,两组患者活动体力限制、情绪控制、症状及社会限制评分均明显下降(P<0.05),且观察组下降程度更大(P<0.05);观察组和对照组患者不良反应发生率相当(10.77%比12.31%,P>0.05)。结论丹参多酚酸盐联合康复教育对冠心病患者具有积极的治疗作用,可帮助患者提升运动耐量,显著降低患者血清中Hcy,TGF-β1,BNP,IFN-γ水平,改善生活质量,且临床使用较安全,建议推广。

Objective To investigate the effect of salvianolate combined with rehabilitation education on the expression of plasmahomocysteine（Hcy）,serum transforming growth factor-β1（TGF- β1） and quality of life in patients with coronary heart disease（CHD）.Methods Totally 130 CHD patients admitted to our hospital from December 2015 to Januat7 2017 were divided into the observationgroup and the control group according to random number table method,65 cases in each group. The patients in the two groups contin-ued to treat underlying diseases, and Salvianolate Injection was administered intravenously, once a day for 1 consecutive month.Results Compared with before treatment, the total exercise time and ST segment depression 1 mm time of the two groups wereincreased obviously, the maximal exercise tolerance increased obviously, and the improvement of the observation group was more obvious（P 〈 0.05）. After treatment,the levels of Hcy,TGF- [31,BNP,IFN-7 in the two goups were lower than those before treatment（P 〈 0.05）,but there was no significant difference between the two groups（P 〉 0.05）. After treatment,the scores of physical activity limitation,emotional control,symptom and social limitation in the two groups were lower than those before treatment（P 〈 0.05）,and the decreasein the observation group was more signiflcant（P 〈 0.05）.The incidence rate of adverse reactions in the two groups was similar（10.77% vs. 12.31%, P 〉 0. 05）. Conclusion Salvianolate combined with rehabilitation education has a positive therapeutic effect onpatients with CHD,which can help patients to improve exercise tolerance, significantly reduce the levels of Hcy, TGF-I31,BNP andIFN-7 in serum and improve their quality of life,and the clinical use is safer,which is recommended to be popularized.