孟鲁司特治疗肺炎支原体肺炎伴喘息患儿临床评价

Clinical Evaluation on Montelukast in the Treatment of Children Patients with Mycoplasma Pneumonia Complicated with Wheezing

目的观察孟鲁司特治疗肺炎支原体肺炎(MPP)伴喘息患儿的疗效及对小气道的影响。方法采用随机数字表法将2015年1月至12月收治的88例MPP伴喘息的住院患儿随机分为3组(常规治疗组,孟鲁司特干预组,布地奈德干预组),出院后随访6个月;另选择20例健康儿童作为对照组。结果治疗后,临床症状改善方面,布地奈德干预组、孟鲁司特干预组与常规治疗组比较,差异有统计学意义(P<0.01),布地奈德干预组与孟鲁司特干预组之间无显著性差异(P>0.05);治疗后,布地奈德干预组、孟鲁司特干预组患儿常规肺功能及小气道功能与常规治疗组比较,差异有统计学意义(P<0.01),布地奈德干预组、孟鲁司特干预组之间无显著性差异(P>0.05)。结论 MPP伴喘息患儿在急性期常规抗感染的同时加用孟鲁司特可改善肺功能,特别是可缓解小气道阻塞情况,可在急性期较快缓解咳嗽喘息症状,有效地控制病情,同时可有效减少肺炎支原体感染后喘息的发生。

Objective To observe the clinical effect of montelukast in the treatment of children patients with mycoplasma pneumonia（MPP） complicated with wheezing and its effect on the small airway. Methods Totally 88 hospitalized children patients with MPPcomplicated with wheezing admitted to our hospital from January to December in 2015 were divided into 3 groups （conventional treat-ment group, montelukast intervention group,budesonide intervention group） by random number table method. The children patients werefollowed up for 6 months after discharge,and 20 healthy children were selected as the control group. Results After treatment,the im-provements of clinical symptoms in the budesonide intervention group and montelukast intervention group were statistically different fromthose in the conventional treatment group（P 〈 0. 01） , while there was no statistically significant difference between the budesonide in-tervention group and montelukast intervention group（P 〉 0. 05）. After treatment,the routine pulmonary function and small air, ray func-tion of children patients in the budesonide intervention group and montelukast intervention group were statistically diftrent from thosein the conventional treatment group（P 〈 0. 01）,while there was no statistically significant difference between the budesonide interven-tion group and montelukast intervention group（P 〉 0.05）. Conclusion Conventional anti-infection combined with montelukast in thetreatment of children patients with MPP complicated with wheezing at the acute stage can improve pulmonary function, especially canrelieve the small airway obstruction,it can quickly relieve the symptoms of cough and wheezing at the acute stage,effectively control thecondition and reduce the incidence of wheezing after MPP infection.