氨磺必利和利培酮对精神分裂症患者泌乳素及孕酮的影响比较

Comparative Effects Between Amisulpride and Risperidone on Levels of Prolactin and Progesterone of Schizophrenia Patients

目的比较氨磺必利和利培酮对精神分裂症患者血清中泌乳素及孕酮水平的影响。方法选取医院2013年6月至2015年6月收治的精神分裂症患者80例,按照随机数字表法分为利培酮治疗组(50例)及氨磺必利治疗组(30例)。结果治疗后,两组患者阳性症状评分、阴性症状评分及总评分均显著降低(P<0.05),但组间比较差异无统计学意义(P>0.05);治疗后,两组患者血清泌乳素水平均显著升高,孕酮水平均显著降低(P<0.05),但组间比较无统计学差异(P>0.05);利培酮治疗组总有效率为86.00%,与氨磺必利治疗组的86.67%相当(χ~2=0.295,P=0.737);两组患者锥体外系反应等不良反应发生率相当(P>0.05)。结论氨磺必利和利培酮治疗精神分裂症疗效显著且相当,安全性好,利培酮对患者血清泌乳素及孕酮水平影响更大。

Objective To compare the effect between amisulpride and risperidone on levels of serum prolactin and progesterone ofschizophrenia patients. Methods Totally 80 schizophrenia patients admitted to our hospital from June 2013 to June 2015 were selectedand randomly divided into the risperidone group（n=50） and the amisulpride group（n =30）. Results After treatment, the positivesymptoms score,negative symptom score and total score in the two groups were significantly decreased,hut there was no significant dif-ference between the two groups（P 〉 0.05）.After treatment,the levels of serum prolactin in the two groups were significantly in-creased,while the progesterone in two groups were significantly decreased（P 〈 0. 05）,hut there was no significant difference in the twogroups（P 〉 0.05）. The total eftctive rate of the risperidone group was 86. 00% ,which was equivalent to 86. 67% of the amisulpridegroup（x =0. 295, P=0. 737）. There was no significant diftrence in the incidence rate of adverse reactions between the two groups（P 〉 0.05）. Conclusion Amisulpride and risperidone in the treatment of schizophrenia have significant and similar effects and highsafety,hut risperidone has a greater effect on the levels of serum prolactin and progesterone in patients.