血常规联合C-反应蛋白检测在疟疾诊断中的意义

Significance of routine blood test combined with C-reactive protein in the diagnosis of malaria

目的探讨发热患者的血常规四项指标、血小板数量及C-反应蛋白与疟疾的关系,为提示疟疾病原学检测提供依据。方法选取2008—2016年在长江水利委员会长江医院诊断及治疗的输入性疟疾病案资料,对比分析每例患者治疗前、后血细胞计数、血小板数量及C-反应蛋白的变化。结果共收集53例输入性疟疾病案资料,其中间日疟41例、恶性疟12例;治疗前、后病例血常规指标中红细胞(RBC)、血红蛋白(HB)差异无统计学意义(P>0.05);白细胞(WBC)治疗前不高或正常;血小板(PLT)治疗前降低者占64.15%,治疗后显著升高,差异有统计学意义(P>0.05);C-反应蛋白(CRP)治疗前升高者占98.11%,治疗后均降至正常。结论结合患者流行病学史,从疟区回归的发热患者若白细胞不高,而血小板降低和C-反应蛋白升高,提示应及时进行疟疾病原学检查,有利于疟疾患者的早诊断和早治疗。

Objective To investigate the relationship between CRP expression and four indexes of routine blood test,especially the change of platelet count in malaria patients,so as to provide reference for malaria prevention and control. Methods It was collected that imported malaria diagnosed and treated in our hospital from 2008 to 2014,and the changes of blood cells,especially platelet count and CRP were analyzed before and after treatment. Results 53 malaria patients included 41 vivax malaria and 12 falciparum malaria. There was no difference in RBC and Hb before and after the treatment. Before treatment,WBC was not high or normal,and64. 15% of patients with PLT decreased. After treatment,PLT significantly increased. 98. 11% of malaria patients CRP was increased before treatment and decreased after treatment. Conclusion Routine blood test combined with CRP in fever patients from malaria area is conducive to early diagnosis and early treatment of malaria.