腹膜透析患者发生代谢综合征的影响因素

The influence factors of the metabolic syndrome in peritoneal dialysis patients

目的了解腹膜透析(PD)患者代谢综合征(MS)的发生情况,分析相关影响因素。方法选取2014年9月至2016年9月在广西医科大学第一及第二附属医院随访的持续性不卧床腹膜透析(CAPD)患者104例,分为MS组(12例)和非MS组(92例),比较两组临床资料差异,分析影响PD患者发生MS的相关因素。结果 104例患者中,MS组12例(11.5%),MS组与正常组比较,年龄、尿量、血磷及尿酸有统计学意义。超重组20例(19.2%),年龄、高密度脂蛋白、磷及血清铁较正常组有统计学意义,血脂紊乱31例(29.8%),白蛋白、尿酸及D/P较正常组有统计学意义。高血糖者10例(9.6%),血红蛋白和舒张压较正常组的差异有统计学意义。年龄、血磷是PD合并MS的独立危险因素(P均<0.05)。结论 PD合并MS者具有高龄、高尿酸、高血磷及尿量减少等特点。年龄及血磷是腹透患者发生MS的重要影响因素。

Objective To explore the influence factors of the metabolic syndrome in the continuous ambu-latory peritoneal peptide（CAPD）patients. Methods A total of 104 CAPD in the PD center of the First and theSecond Affiliated Hospital of Guangxi Medical University from June 2014 to June 2016 were enrolled in this study.Patients were divided into the metabolic syndrome（MS）and the non-metabolic syndrome（non-MS）group. Theclinical data of patients with MS and non-MS was compared,and the influence factors of the MS in PD patientswere analyzed. Results Twelve patients were diagnosed as metabolic syndrome. Significant differences in age,urine volume,serum phosphorus（P）and uric acid（UA）were observed between group MS and non-MS（P〈0.05）.Twenty people were overweight,with the prevalence rate of 19.2%. Compared with the normal and overweightgroup,age,high density lipoprotein（HDL）,P and serum iron were statistically significant（P〈0.05）. Thirty-one people were diagnosed as dyslipidemia,with the prevalence rate of 29.8%. Compared with the normal group,albumin,UA,BMI and D/P were statistically significant in the dyslipidemia group（P〈0.05）. Ten patients werediagnosed as hyperglycemia,with the prevalence rate of 9.6 %. Significant differences in hemoglobin and the dia-stolic blood pressure（DBP）were found between the hyperglycemia group and the normal group（P〈0.05）. Ageand P were shown as independent risk factors for PD patients with MS（P〈0.05,respectively）. Conclusion Theperitoneal dialysis patients were more likely to have metabolic syndrome than the normal population. Age and serumphosphorus are the factors influencing the occurrence of MS in peritoneal dialysis patients.