胃蛋白酶在咽喉反流与喉癌中的临床意义及研究进展

Clinical significance and research progress of pepsin in laryngopharygeal reflux and laryngeal carcinoma

喉癌的发病率位居头颈部肿瘤第2位,在我国占全部头颈部鳞状细胞癌近50%[1],仍然是上呼吸消化道恶性肿瘤中最主要的死亡原因之一。喉癌的危险因素有很多,包括吸烟、饮酒以及HPV感染等,而现在越来越多的研究提示咽喉反流（laryngopharygeal reflux,LPR）也是喉癌重要的危险因素之一。与食管黏膜相比,

Laryngeal carcinoma is a common malignancy,and the incidence of this disease is on the rise.In recent years,more and more studies of the etiology and risk factors have confirmed the correlation between laryngopharygeal reflux and the incidence of laryngeal carcinoma.Laryngopharygeal reflux is defined as reflux of the stomach contents above the upper esophageal sphincter.Stimulation and injury of acid to the esophagus and throat mucosa have now been studied more thoroughly,and pepsin plays an increasingly important role in laryngopharygeal reflux disease.The incidence of laryngopharygeal reflux in patients with laryngeal carcinoma reported in the literature was 54.0%-88.7%,mainly because of mucosal injury due to the combined effect of gastric acid and pepsin.This article reviews the significance of pepsin in laryngopharygeal reflux,its mechanism of action and related clinical detection methods.