ceRNA在头颈部肿瘤中的研究进展

The research progress of ceRNA in the head and neck carcinoma

头颈部肿瘤为高发肿瘤,其中超过90%为鳞状细胞癌[1]。头颈部鳞状细胞癌（squamous cell carcinoma of the head and neck）是指发生于口腔、咽部及喉部、食管上段的由鳞状上皮覆盖的恶性肿瘤,是全球范围内第6位常见的恶性肿瘤,每年约有100多万新发病例,其他类型的头颈部肿瘤如甲状腺乳头状瘤、鼻咽癌的发病率也逐渐增高[2-3]。人们一直在不断地摸索和提高治疗水平,

Competitive endogenous RNA（ceRNA）refers to the regulatory model that RNAs can regulate each other＇s expression by competing for common miRNA response elements at post-transcriptional levels.The ceRNA network links the function of protein-coding genes（mRNAs）with the functions of non-coding RNAs（such as miRNAs,long non-coding RNAs,pseudogenes transcripts,and circular RNAs）and plays an important role in the development of multiple tumors.The head and neck carcinoma is a highly aggressive malignant tumor.Although the treatment methods continue to improve,the survival rate of head and neck carcinoma patients has no more significant improvement.It is particularly important to explore the molecular mechanisms of the development and metastasis of head and neck carcinoma,look for specific molecular diagnostic markers and therapeutic targets.We summarize the role of ceRNA regulatory networks in the development of head and neck carcinoma in the present review.