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便通胶囊对比芪蓉润肠口服液治疗抗精神病药物所致药源性便秘的临床疗效研究 被引量:9

Clinical Effects of Biantong Capsules Compared with Qirong Runchang Oral Liquid in the Treatment of Patients with Drug-induced Constipation Caused by Antipsychotics
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摘要 目的:对比观察便通胶囊和芪蓉润肠口服液治疗抗精神病药物所致药源性便秘的临床疗效与安全性。方法:选取2014年10月至2016年08月北京市怀柔区中医医院收治的精神障碍患者100例,按照随机数字表法,随机分为2组,对照组和观察组。所有患者备用治疗便秘药物,当便秘发生时给予及时治疗,对照组给予芪蓉润肠口服液,观察组给予便通胶囊,随访和观察期为1年。观察便秘发生率、便秘症状评分、便秘总有效率、平均服药天数和不良反应。结果:2组便秘发生率比较,差异无统计学意义(P>0.05);观察组因为治疗3 d,便秘仍未缓解而退出研究者显著少于对照组(P<0.05);观察组便秘症状评分、平均服药天数均显著低于对照组(P<0.05),观察组愈显率显著高于对照组(P<0.05);2组总不良反应发生率比较,差异无统计学意义(P>0.05)。结论:便通胶囊和芪蓉润肠口服液均是治疗抗精神病药物所致便秘的有效药物,但便通胶囊疗效与安全性更好,值得临床推广使用。 Objective: To compare the clinical effects and safety of Biantong Capsules and Qirong Runchang Oral Liquid in the treatment of patients with drug-induced constipation caused by antipsychotics. Methods: A total of 100 patients with schizophrenia were admitted and treated in Huairou Hospital of Traditional Chinese Medicine from October 2014 to August 2016. All the patients were prepared with constipation drugs. According to random number table,patients were randomly divided into two groups,the control group( Qirong Runchang Oral Liquid) and the observation group( Biantong Capsules). And the observation period and followup visit was for one year to observe the incidence of constipation,the constipation symptom score,total effective rate of constipation,average days of medicine taken and adverse reactions of the two groups' patients. Results: The constipation incidence of two groups had no significant difference( P〈0. 05); Cases that withdrawn from the study because of no relief of constipation for 3 days of treatment in the observation group were fewer than those in the control( P〈0. 05); The symptom score and average days of medicine taken were lower than those in the control group( P〈0. 05),while the cure-remarkable-effectiveness rate of constipation in the observation group was higher than that in the control group( P〈0. 05); And there was no significant difference in the incidence of adverse reactions between the two groups( P〈0. 05). Conclusion: Biantong Capsules and Qirong Runchang Oral Liquid were both effective in the treatment of constipation induced by antipsychotic,and the effects and safety of Biantong Capsules were better which was worthy of clinical promotion.
作者 佟琦媛 王新 Tong Qiyuan;Wang Xin(Eneephalopathy Department, Huairou Hospital of Traditional Chinese Medicine, Beijing 101400, China)
出处 《世界中医药》 CAS 2018年第2期363-365,369,共4页 World Chinese Medicine
关键词 抗精神病物 药源性便秘 便通胶囊 芪蓉润肠口服液 Antipsychotic Drug-induced constipation Biantong Capsules Qirong Runchang Oral Liquid
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