1Aloysius MM, Zaitoun AM, Bates TE, et al. Complete absence of M2-pyruvate kinase expression in benign pancreatic ductal epithelium and pancreaticobiliary and duodenal neoplasia [ J ]. BMC Cancer, 2009,9 : 327 - 334.
2Warburg O. On the origin of cancer cells [ J ]. Science, 1956,123 (3191) :309 - 314.
3Boros LG, Lee WN, Go VL. A metabolic hypothesis of cell growth and death in pancreatic cancer [J]. Pancreas, 2002,24( 1 ) :26 -33.
4Christofk HR, Vander Heiden MG, Harris MH, et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth [J].Nature,2008, 452(7184) :230 -233.
5Christofk HR, Vander Heiden MG, Wu N, et al. Pyruvate kinase M2 is a phosphotyrosine-binding protein [ J ].Nature ,2008,452(7184) : 181 - 186.
6Mazurek S. Pyruvate kinase type M2: a key regulator within the tumour metabolome and a tool for metabolic profiling of tumours[ J ]. Ernst Schering Found Symp Proc, 2007 (4) : 99 - 124.
7Yeh CS, Wang JY, Chang FY, et al. Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers [ J ]. Oncol Rep,2008,19(1) :81 -91.
8Guminska M, Ignacak J, Kedryna T, et al. Tumor-specific pyruvate kinase isoenzyme M2 involved in biochemical strategy of energy generation in neoplastic cells [J]. Acta Biochim Pol, 1997,44. (4) :711 - 724.
9Hacker HI, Steinberg P, Bannasch P. Pyruvate kinase isoenzyme shift from L-type to M2-type is a late event in hepatocarcinogenesis induced in rats by a choline- deficient/DL-ethionine-supplemented diet [ J ]. Carcinogenesis, 1998,19( 1 ) :99 - 107.
10Ashizawa K, Willingham MC, Liang CM, et al. In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate [ J]. J Biol Chem, 1991,266 (25) : 16842 - 16846.
