血浆致动脉粥样硬化指数和颈动脉内膜中层厚度在白塞病中水平及相关性分析

Behcet's Disease and Correlation Analysis of AIP and cIMT Levels

目的明确在白塞病(Behcet's disease,BD)患者中颈动脉内膜中层厚度(carotid artery intima-media thickness,c IMT)及血浆致动脉粥样硬化指数(atherogenic index of plasma,AIP)是否升高以及AIP与c IMT的相关性。方法纳入BD患者42例,行体检的健康对照组42例,行c IMT测量并计算AIP,对数据行相关性分析。结果 BD组c IMT及AIP值均高于对照组,差异有统计学意义;BD患者的c IMT和BMI、病程、TG水平、CRP水平之间呈正相关;c IMT和HDL-C水平之间呈负相关;AIP和BMI、TG水平、CRP水平、ESR水平之间呈正相关;AIP和HDL-C水平之间有负相关;c IMT与AIP之间具有正相关关系。结论在BD患者中检测c IMT和AIP可早期筛查发生动脉粥样硬化的高危人群,达到早期预防治疗、改善预后的目的。

Objective To determine whether cIMT（carotid intima media thickness） and AIP（atherogenic index of plasma） are elevated in BD（Behcet＇s disease） patients and analyze the correlation of BD with AIP and cIMT. Method A total of 42 BD patients and 42 healthy control cases who administered physical examination were enrolled. They went through cIMT measurement and AIP assay,based on which the correlation analysis was conducted. Result cIMT and AIP are both higher in the BD group than in the control group,showing statistically significant difference. In BD cases,cIMT is positively related with BMI,TG level and CRP level,but negatively related with HDL-C level; AIP is positively related with BMI,TG level,CRP level and ESR level,while is negatively related with HDL-C level. There is positive correlation between cIMT and AIP. Conclusion In BD patients,cIMT and AIP assays allows early screening of high risk population with atherosclerosis to realize the purpose of early prevention,treatment and prognosis improvement.