RN181基因对肿瘤的抑制作用及其进展

Inhibition Mechanism of RN81 Gtene on Cancer and its Progress

原发性肝癌是临床上常见的恶性肿瘤之一,我国是肝癌发病大国,其死亡率较高。目前外科手术切除仍然是治疗肝癌最主要的方式,但术后往往发生复发,且对化疗效果欠佳,长期发展易发生远处转移。然而,对于晚期发生转移的肝癌,目前尚无有效的治疗方法。RN181基因是一种全新的抑癌基因,然而,目前对RN181报道甚少,且该基因对肿瘤的抑制作用尚不明确;因此,本文旨在对RN181基因对肿瘤的抑制作用进行综述,为肝癌及与该基因相关的其他肿瘤的靶向治疗提供新的方向。

Primary liver cancer is one of common clinical malignant tumor. The rate of liver cancer in China is very high,and the mortality rate is high. Current surgical resection is still the most main way in treatment of liver cancer,but the postoperative recurrence often occurs,and the rightness of chemotherapy is inefficient and is prone to long-term development of distant metastasis. For metastatic hepatic carcinoma,there is no effective treatment currently. RN181 is a new kind of tumor suppressor gene,however,at present the articles of RN181 report less,and the effect of the gene on the tumor inhibition is still not clear. Therefore,the RN181 of tumor inhibition is reviewed in the study,to provide a new direction of targeted therapy for liver cancer and other tumors associated with the gene.