植物生长调节剂的毒理作用及其损害雄性生殖健康的研究进展

Toxicological characteristics of plant growth regulators and their impact on male reproductive health

植物生长调节剂(PGRs)与植物激素具有相似的生理作用和生物学效应,因而在农林业中应用越来越广泛。过度依赖PGRs促进植物生长所导致的农产品药物残留严重危害了人类的身体健康。研究证实,PGRs对人类及动物具有肝毒性、胰腺毒性、免疫毒性、遗传毒性和神经毒性,甚至致癌和致畸。另外,对人类和动物生殖系统也具有极大损害。本文集中讨论了PGRs可引发的各种毒性作用及相关机制的研究进展,并针对其损害雄性生殖系统健康的发生机制进行了归纳与总结,旨在引起人们对PGRs在食品或环境中的残留问题及安全问题的重视,最大限度降低PGRs对于人类健康的危害作用。

Plant growth regulators （PGRs） have similar physiological and biological effects to those of plant hormones, and therefore are used widely in agroforestry. The residues of PGRs in agricultural products are seriously detrimental to human health be- cause they have been found with hepatotoxicity, nephrotoxicity, genotoxicity, neurotoxicity, even carcinogenicity and teratogenicity. Furthermore, PGRs are suspected to disrupt the function of human and animal reproductive systems. This paper presents an overview on various toxicities of PGRs on human and animal reproductive health and their underlying mechanisms, aiming to arouse people＇s at- tention to PGR residues in food and environment and reduce PGR-induced damage to the male reproductive system and to human health as well.