摘要
The l2 catalyzed highly selective oxidatve condensation of cydohexenones and alcohols for the synthesis of aryl atkyl ethers has been described. DMSO is employed as the mild terminal oxidant. This novel methodology offers a metal-free reaction condition, operational simplicity and broad substrate scope to afford valuable products from inexpensive reagents. Various meta-substituted aromatic ethers which are hardly synthesized from the reported methods requiring meta-substituted phenols, are efficiently prepared by the present protocol.
The l2 catalyzed highly selective oxidatve condensation of cydohexenones and alcohols for the synthesis of aryl atkyl ethers has been described. DMSO is employed as the mild terminal oxidant. This novel methodology offers a metal-free reaction condition, operational simplicity and broad substrate scope to afford valuable products from inexpensive reagents. Various meta-substituted aromatic ethers which are hardly synthesized from the reported methods requiring meta-substituted phenols, are efficiently prepared by the present protocol.
基金
Acknowledgement We thank the National Natural Science Foundation of China （Nos. 21325206, 21632001, 21772002）, National Basic Research Program of China （973 Program） （No. 2015CB856600）, National Young Top-notch Talent Support Program, and Peking University Health Science Center （No. BMU20160S41）for financial support of this work. We thank Xiaojing Wen in this group for reproducing the results of 3fa and 3na.
