真核生物集缩素SMC2/SMC4异二聚体的结构解析研究进展

The Progress of Structure Analysis of SMC2/SMC4 Heterodimer of Eukaryotic Condensin

真核生物集缩素(condensin)的主要作用是在细胞周期过程中调控染色体的动态变化。它是一种含5个亚基的蛋白质,由1个起核心催化作用的SMC2(structure maintenance of chromosomes 2)/SMC4异二聚体和3个起调节作用的非SMC亚基组成。目前,关于集缩素中SMC2/SMC4异二聚体的体内构象和分子作用机制仍不清楚。最近,对SMC2/SMC4异二聚体的结构解析取得许多新进展。该文在简要介绍SMC蛋白的基本结构、真核生物集缩素的发现、真核生物集缩素的结构组成的基础上,对近年来SMC2/SMC4异二聚体的结构解析的研究进展作一综述,以期为相关研究提供参考。

The main role of eukaryotic condensin is to regulate the chromosome behavior during cell cycle. It is a pentameric protein complex that comprises a core catalytic SMC2/SMC4 heterodimer and three regulatory non-SMC subunits. At present, it is still unclear about the conformation in vivo and molecular mechanism of SMC2/ SMC4 heterodimer of eukaryotic condensin. Recently, many novel progresses have been made in the studies of the structure analysis of SMC2/SMC4 heterodimer. This paper reviewed research progresses of the structure analysis of SMC2/SMC4 heterodimer in recent years in order to provide references to related study on the basis of briefly introduce of primary structure of SMC proteins, the found of eukaryotic condensin and structure and composition of eukaryotic condensin.