宫颈癌和宫颈上皮内瘤变与血清肿瘤坏死因子受体的相关性分析

Correlation of serum level of tumor necrosis factor receptors with cervical cancer and cervical intraepithelial neoplasia

目的探讨宫颈癌和宫颈上皮内瘤变与血清肿瘤坏死因子受体表达水平的相关性。方法选择2015年1月至2017年1月我院妇科收治的915例中老年女性患者为研究对象。按临床疾病诊断情况分为5组，其中A组432例，为未检出宫颈癌及宫颈上皮内瘤变的对照组；B组89例，为宫颈上皮内瘤变Ⅰ型患者；C组94例，为宫颈上皮内瘤变Ⅱ型患者；D组175例，为宫颈上皮内瘤变Ⅲ型患者；E组125例，为宫颈癌患者。采集入选患者外周血液样本，使用酶联免疫吸附法测定血清肿瘤坏死因子受体表达水平。结果sTNFR Ⅰ水平A、B、C、D和E组分别为（0.869±0.243）μg/L、（1.127±0.435）μg/L、（1.164±0.471）μg/L、（1.206±0.693）μg/L和（1.836±1.216）μg/L；A组患者血清sTNFR Ⅰ水平明显低于B、C、D、E组（t＝7.782、8.741、8.860和15.523，均P〈0.001）。E组患者血清sTNFR Ⅰ水平明显高于B、C和D组（t＝5.263、5.077和5.684，均P〈0.001）。B、C和D三组间血清sTNFR Ⅰ水平比较差异无统计学意义（均P〉0.05）。sTNFR Ⅱ水平A、B、C、D和E组分别为（1.633±0.402）μg/L、（1.872±0.526）μg/L、（1.895±0.402）μg/L、（1.946±0.604）μg/L和（3.192±1.145）μg/L；A组患者血清sTNFR Ⅱ水平明显低于B、C、D、E组（t＝4.824、5.254、7.446和23.731，均P〈0.001）。E组患者血清sTNFR Ⅱ水平明显高于B、C和D组（t＝10.136、10.501和12.216，均P〈0.001）。B、C和D三组间血清sTNFR Ⅱ水平比较差异无统计学意义（均P〉0.05）。结论宫颈癌和宫颈上皮内瘤变的发生与血清肿瘤坏死因子受体具有相关性。

ObjectiveTo investigate the correlation of cervical cancer and cervical intraepithelial neoplasia with expression level of serum soluble tumor necrosis factor receptor Ⅰ and Ⅱ.MethodsA total of 915 recruited women in middle or advanced age were treated in our hospital from January 2015 to January 2017.Participants were assigned to one of five groups： group A （n=432） as control subjects; group B （n=89） diagnosed as cervical intraepithelial neoplasia Ⅰ; group C （n=94） as cervical intraepithelial neoplasia Ⅱ; group D （n=175） as cervical intraepithelial neoplasia Ⅲ; group E （n=125） as cervical cancer.The expression level of serum tumor necrosis factor receptor （sTNFR） was detected by enzyme linked immunosorbent assay.ResultsThe level of sTNFR Ⅰ was much lower in the group A （0.869±0.243）μg/L than in the group B （1.127±0.435）μg/L, C （1.164±0.471）μg/L, D （1.206±0.693）μg/L, and E （1.836±1.216）μg/L （t=7.782, 8.741, 8.860, and 15.523, all P〈0.001）. The level of sTNFR Ⅰ in the group E was much higher than in the groups B, C, and D （t=5.263, 5.077, and 5.684, all P〈0.001）. No statistical significance was found in sTNFR Ⅰ level between B, C and D groups.The level of sTNFR Ⅱ was much lower in the group A （1.633±0.402）μg/L than in the group B （1.872±0.526）μg/L, C （1.895±0.402）μg/L, D （1.946±0.604）μg/L, and E （3.192±1.145）μg/L （t=4.824, 5.254, 7.446, and 23.731, all P〈0.001）. The level of sTNFR Ⅱ was much higher in the group E than in the groups B, C, and D （t=10.136, 10.501, and 12.216, all P〈0.001）. There was no significant difference in sTNFR Ⅱ levels between the groups B, C, and D groups （all P〉0.05）.ConclusionsCervical cancer and cervical intraepithelial neoplasia are correlated with level of serum tumor necrosis factor receptors.