注射用益气复脉(冻干)药理作用及临床研究进展

Pharmacological effects and clinical research progress of Yiqi Fumai Lyophilized Injection

注射用益气复脉(冻干)源于经典古方生脉散,由红参、麦冬和五味子3味中药组成,临床上主要用于治疗冠心病劳累型心绞痛及慢性心功能不全等心血管系统疾病。现代药理研究表明注射用益气复脉(冻干)具有增强心脏收缩功能、延缓心室重构、改善能量代谢、改善微循环障碍以及抗氧化等药理作用。就近10年注射用益气复脉(冻干)的药理作用、临床应用以及不良反应发生情况等内容进行综述,为临床上更加安全合理用药提供依据和参考。

Yiqi Fumai Lyophilized Injection（YQFM） is a modern preparation derived from the famous ancient prescription of Sheng-mai San, consisting of three traditional Chinese herbal medicines of Panax ginseng, Ophiopogon japonicus and Schisandra chinensis, mainly used in the clinical treatment of angina pectoris of coronary heart disease, chronic heart failure and other cardiovascular diseases. Modern pharmacological research shows that YQFM has the pharmacological effects of enhancing cardiac contractility, delaying ventricular remodeling, resisting myocardial ischemia/anoxia, improving microcirculation disturbance and anti-oxidation. Pharmacological effects, clinical application and adverse reactions of YQFM in recent 10 years were reviewed in this article, so as to provide evidence and reference for safer and rational drug use in clinic.