注射用益气复脉(冻干)化学成分及质量控制研究进展

Research progress on chemical composition and quality control of Yiqi Fumai Lyophilized Injection

注射用益气复脉(冻干)处方源于经典古方生脉散,由红参、麦冬和五味子3味中药组成,主要化学成分为三萜皂苷类、甾体皂苷类、木脂素类、糖类及其他成分。临床上主要用于治疗冠心病劳累型心绞痛及慢性心功能不全等心血管系统疾病。本文就近10年注射用益气复脉(冻干)的化学成分、药材质量评价、产品质量控制方法以及配伍稳定性研究进行综述,为临床上更加安全合理用药提供依据和参考。

Yiqi Fumai Lyophilized Injection is a modern preparation derived from the famous ancient prescription of Sheng-mai San,consisting of three traditional Chinese medicines of Panax ginseng, Ophiopogon japonicas, and Schisandra chinensis. The main chemical components are triterpenoid saponins, steroid saponins, lignans, carbohydrates, and other ingredients. It is mainly used for the treatment of cardiovascular diseases such as angina pectoris of coronary heart disease and chronic cardiac insufficiency. In this article, the contents of chemical components, quality control of raw materials and preparation, and compatibility in the past 10 years are reviewed, providing a basis and reference for safer and rational drug use in clinic.