功能性便秘患者胃分泌功能改变的实验研究

Study on Altered Gastric Secretary Function in Patients with Functional Constipation

目的:了解功能性便秘患者胃分泌功能,明确有无胃肠轴激动。方法研究纳入51例体检者为对照组,42例功能性便秘患者为便秘组,检测各组清晨胃液pH值、血清胃泌素17(G-17)、胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)水平以及幽门螺杆菌感染比率并进行统计学分析。结果对照组和便秘组患者Hp阳性率、PGⅡ水平差异无统计学意义(Hp阳性率:χ~2=0.031,P=0.861;PGⅡ:t=1.666,P=0.100),两组间胃液pH值,G-17和PGⅠ水平差异具有统计学意义(pH值:t=2.180,P=0.032;G-17:t=2.703,P=0.008;PGⅠ:t=7.388,P<0.001)。结论功能性便秘患者胃分泌功能亢进,提示功能性便秘患者可能存在胃肠分泌轴激动并促进胃酸分泌。

Objective In order to detect gastric fluid pH value,Gastrin-17（G-17）,pepsinogen Ⅰ（PGⅠ）,pepsinogen Ⅱ（PGⅡ）and figure out gastric secretory function in patients of functional constipation（FC）.Methods 51 healthy individuals were chosen as control group and 42 patients with FC were chosen as FC group,of which serum gastric fluid pH value,Hp ratio,G-17,PGⅠand PGⅡ were detected and analyzed.Results Compared with control group,gastric fluid pH value were marked reduced（t=2.180,P=0.032）,and G-17,PGⅠlevel in blood were marked increased in FC group（G-17：t=2.703,P=0.008;PGⅠ：t=7.388,P〈0.001）.Hp ratio and blood level of PGⅡ in two groups showed no significant difference（Hp ratio：χ~2=0.031,P=0.861;PGⅡ：t=1.666,P=0.100）.Conclusion Increased gastric secretory function level were found in patients of functional constipation.It gave a hint that stimulated gastroenteritic axis existed in patients of functional constipation.