摘要
目的探讨卵巢癌患者术前血常规部分参数的变化意义。方法以29例卵巢癌和30例卵巢良性肿瘤患者为研究对象,计算得出中性粒细胞与淋巴细胞比值(NLR),淋巴细胞和单核细胞比值(LMR),红细胞分布宽度(RDW),血小板和淋巴细胞比值(PLR)和CA-125水平;依据病理对卵巢癌患者临床分期,分析NLR,LMR,RDW,PLR及CA-125水平在不同分期中的差异;以是否为卵巢癌分组,对上述参数绘制ROC曲线。结果实验组和对照组NLR,LMR,RDW,PLR和CA-125水平分别为2.49±1.04vs 1.46±0.45,4.48±1.56vs 6.67±1.87,175.35±62.86vs 127.11±41.99,(12.98±0.98)%vs(12.48±0.76)%,(355.9±369.73)U/ml vs(12.87±6.91)U/ml,差异均具有统计学意义(t=4.979,4.879,3.477,2.188,5.082,均P<0.05);卵巢癌患者Ⅰ+Ⅱ期与Ⅲ+Ⅳ期上述各项参数比较差异均有统计学意义(t=3.379,2.740,3.855,2.940,3.226,均P<0.05);NLR,LMR,RDW,PLR四参数及血清CA-125水平受试者工作特征曲线法判断卵巢癌的ROC曲线下面积分别为0.874,0.823,0.749,0.680和0.905。结论部分血常规参数可辅助诊断良恶性卵巢肿瘤,且在卵巢癌临床分期的判断中有积极的意义。
Objective To explore the changes of preoperative blood parameters of ovarian cancer patients.Methods The population that we studied consisted of 29 patients with ovarian cancer and 30 cases of ovarian benign tumors controls,calculated neutrophils and lymphocytes ratio(NLR),lymphocytes and monocytes ratio(LMR),red blood cell distribution width(RDW),platelet and lymphocyte ratio(PLR)and CA-125 levels.According to the clinical stage of ovarian cancer patients,the differences of NLR,LMR,RDW,PLR and CA-125 were analyzed in different stages.The above parameters were used to draw the ROC curve for ovarian cancer.Results The average NLR,LMR,RDW,PLR and CA-125 value in experimental and controlled were 2.49±1.04 vs 1.46±0.45,4.48±1.56 vs 6.67±1.87,175.35±62.86 vs 127.11±41.99,(12.98±0.98)% vs(12.48±0.76)% and(355.9±369.73)U/ml vs(12.87±6.91)U/ml respectively.The differences were statistically significant(t=4.979,4.879,3.477,2.188,5.082,all P〈0.05).(Ⅰ+Ⅱ)stage and(Ⅲ+Ⅳ)stage of ovarian cancer patients in the above-mentioned parameters mean differences were statistically significant(t=3.379,2.740,3.855,2.940,3.226,all P〈0.05).The area under ROC of NLR,LMR,RDW,PLR and CA-125 value in diagnosing ovarian cancer were 0.874,0.823,0.749,0.680 and 0.905 respectively.Conclusion Some blood routine parameters can be used to identify benign and malignant ovarian tumors,and have positive significance in the clinical staging of ovarian cancer.
作者
徐金良
杜丹丹
翟志敏
郭进京
XU Jin-liang;DU Dan-dan;ZHAI Zhi-min;GUO Jin-jing(a. Department of Obstetrics and Gynecology, 1b. Department of Clinical Laboratory, the Fuyang People ' s Hospital Affiliated to Anhui Medical University ,Anhui Fuyang 236400, China;Department of Cardiology, Fuyang Second People ' s Hospital ,Anhui Fuyang 236400, China;Department of Hematology ,the Second Hospital Affiliated to Anhui Medical University ,Hefei 230061 ,China)
出处
《现代检验医学杂志》
CAS
2018年第2期16-18,22,共4页
Journal of Modern Laboratory Medicine
基金
国家自然科学基金(81670179)