急性脑梗死并发幽门螺旋杆菌感染者血脂水平及氧化应激反应的观察

Observation of Serum Lipid Level and Oxidative Stress Response in Patients with Acute Cerebral Infarction Complicated with Helicobacter Pylori Infection

目的通过检测急性脑梗死(ACI)并发幽门螺旋杆菌(Hp)感染者血清血脂和丙二醛(MDA)水平及超氧化物歧化酶(SOD)活性,观察Hp感染对血脂代谢及氧化应激反应的影响。方法选择ACI组350例和对照组80例,检测血清Hp-IgG抗体(胶体金法)和^(14)C尿素呼气试验(^(14)C-UBT),采用美国贝克曼库尔特AU680全自动生化分析仪检测血清血脂及SOD活性(比色法),采用上海现科752可见分光光度计(532nm)检测血清MDA水平(TBA法)。结果 ACI组Hp感染率(69.5%)显著高于对照组(33.8%),差异有统计学意义(χ~2=18.882,P<0.01)。Hp感染组与Hp非感染组比较,血清TC,TG,LDL-C及HDL-C水平差异均具有统计学意义(t=4.167~5.521,均P<0.01)。对照组、Hp非感染组及Hp感染组的血清MDA水平和SOD活性差异均具有统计学意义(F=34.891,46.613,均P<0.01)。Hp感染组与Hp非感染组血清MDA水平和SOD活性比较差异具有统计学意义(t=5.197,9.713,P<0.01),Hp非感染组与对照组比较差异也具有统计学意义(t=3.173,8.228,P<0.01)。结论急性脑梗死并发幽门螺旋杆菌感染者,机体内血脂代谢紊乱加剧及氧化应激反应增强,此可能是幽门螺旋杆菌感染加剧急性脑梗死病情的原因之一。

Objective To observe the Hp infection effect on blood lipid metabolism and oxidative stress through detecting acute cerebral infarction（ACI）with Helicobacter pylori（Hp）infection serum lipid and malondialdehyde（MDA）level and superoxide dismutase（SOD）activity.Methods Chose ACI 350 cases of ACI group,80 cases of control group and detected serum Hp-IgG antibody（by colloidal gold）and ^（14）C urea breath test（by ^（14）C-UBT）.Used the American beckman coulter AU680 fullautomatic biochemical analyzer to detect the serum lipid and SOD activity（colorimetry）,and used Shanghai now752 visible spectrophotometer（532 nm）to detect the serum MDA level（TBA）.Results The Hp infection rate of ACI group（69.5%）was significantly higher than that in the control group（33.8%）,the differences was statistically significant（χ~2=18.882,P〈0.01）.The differences in serum TC,TG,LDL-C and HDL-C levels were statistically significant（t=4.167~5.521,all P〈0.01）compared with Hp non-infection group.The serum MDA level and SOD activity of the control group and Hp infection group were statistically significant（F=34.891~46.613,all P〈0.01）.Hp infection with Hp infection group to compare serum MDA level and SOD activity differences statistically significant（t=5.197,9.713,all P〈0.01）,the Hp infection group and control group in comparative differences were statistically significant（t=3.173,8.228,all P〈0.01）.Conclusion Acute cerebral infarction merger of HP infection,blood lipid metabolic disturbance in body increased and enhanced oxidative stress reaction,this may be intensified HP infection is one of the reasons for acute brain infarction disease.