HBV感染与原发性肝细胞癌的关系及临床意义

The relationship between HBV infection and the occurrence of primary hepatocellular carcinoma and its clinical significance

目的探讨乙型肝炎病毒(HBV)感染与原发性肝细胞癌(PHC)的关系及临床意义。方法选取240例PHC患者作为PHC组,480例健康体检者作为对照组,检测并分析两组研究对象的HBV感染情况,并采用多因素分析法探讨HBV感染与原发性肝细胞癌的关系。结果 PHC组患者的HBV感染阳性率、HBs Ag阳性率、HBe Ag阳性率、抗HBe阳性率、抗HBc阳性率均明显高于对照组(P﹤0.01),抗HBs阳性率明显低于对照组,差异均有统计学意义(P﹤0.01);经非条件Logistic回归分析结果显示:有PHC家族史、有饮酒史、合并HBV感染是发生PHC的独立危险因素(P﹤0.05)。结论 PHC的发病风险由多种因素导致,其中,HBV感染是其重要的发病原因之一。

Objective To investigate the relationship between hepatitis B virus（HBV） infection and the occurrence of primary hepatocellular carcinoma（PHC） and its significance. Method 240 patients with primary PHC（PHC group）and 480 healthy subjects（control group） were included in the study. The HBV infection in both groups was detected and analyzed, multivariate analysis was utilized to explore the relationship between HBV infection and the occurrence of primary PHC. Result The positive rates of HBV infection, HBs Ag, HBe Ag, anti-HBe and anti-HBc in PHC group were significantly higher than those in control group（P〈0.01）, while the positive rate of anti-HBs in PHC group was significantly lower than that in control group（P〈0.01）; non-conditional Logistic regression analysis showed that, family history of PHC, alcohol consumption, and combined HBV infection were independent risk factors of PHC（P〈0.05）. Conclu Conclusion The occurrence of PHC in the population consists of many factors, among which HBV infection is one of the most important causes.