长链非编码RNA与弥漫性大B细胞淋巴瘤关系的研究进展

Research on Ralation of Long Non-coding RNA with Diffuse Large B-cell Lymphomas——Review

弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)发病机制未明,治疗效果差,发生率与死亡率仍在不断攀升,因此探究DLBCL的发病机制与发现新的分子诊断标记和治疗靶点尤为重要。长链非编码RNA(long non-coding RNA,lnc RNA)是真核细胞中一类转录本长度大于200 bp的RNA,可在转录水平及转录后水平调控其靶基因的表达,并参与多种肿瘤的发生、发展、侵袭及转移等过程。近年来长链非编码RNA在弥漫性大B细胞淋巴瘤中的作用不断被发现及证实。本文就HULC、PEG10、Linc RNA-p21、HOTAIR、LUNAR1、MALAT1和SubSig Lnc-17等长链非编码RNA与弥漫性大B细胞淋巴瘤的关系做一综述,希望为相关基础研究及临床诊断和治疗提供新思路。

Diffuse large B-cell lymphoma （DLBCL） accounts for approximately 30% of the non-Hodgkin ＂s lymphoma patients. The underlying molecular mechanism of its pathogenesis is not Well defined and the survival rate of DLBCL patients is very low. Moreover, the annual incidence and mortality of DLBCL is still rising. Accordingly, identification and characterization of new molecular pathways of DLBCL will lead to the development of novel diagnostic markers and molecular therapeutic targets. Long non-coding RNAs （LncRNA） are non-coding RNAs with a length greater than 200 bp in eukaryotic cells, which can regulate the expression of their target genes at the transcriptional and post transcriptional levels, The function of LncRNAs is involved in the initiation, progression, invasion and metastasis of many cancers. Recently, the role of LncRNAs in DLBCL has been identified and intensely studied. This review summarizes the recent discoveries in the expression and function of LncRNAs including HULC, PEGIO, LincRNA-p21, HOTAIR,LUNAR1 ,MALAT1 and SubSigLnc-17 in DLBCL, so as to find potential diagnostic biomarkers and therapeutic targets for DLBCL.