833例次肝静脉压力梯度测定临床分析

Analysis of 833 times measured hepatic venous pressure gradient

目的分析肝静脉压力梯度（HVPG）测定者临床资料，探讨HVPG在肝硬化门静脉高压症诊断、病情评估及指导临床治疗等方面的应用价值。方法收集2010年4月至2017年11月进行HVPG测定的患者资料，分析患者不同HVPG的临床特征及临床意义。结果自2010年4月至2017年11月对确诊肝硬化门静脉高压或临床疑诊患者行HVPG测定833例次，其中123例行2次HVPG测定，共计患者633例。不同病因、不同Child-Pugh分级、不同程度失代偿肝硬化患者HVPG差异有统计学意义。结论HVPG测定对以乙型肝炎为主要病因的肝硬化患者诊断及病情评估是适合的，不同肝硬化严重程度患者HVPG不同，可以指导治疗方案的选择，HVPG测量方法还需要严格规范和质量控制。

Objective To summarize and analyze the clinical data of hepatic venous pressure gradient （HVPG） and to explore the application value of HVPG in the diagnosis, evaluation and clinical treatment of portal hypertension in cirrhosis. Methods The patient data of HVPG measurement performed in Shandong Provincial Hospital from April 2010 to November 2017 were collected, Results A total of 633 patients with 833 times of HVPG measurements were included. There was significant difference in HVPG between patients with different etiologies, different Child-pugh grades and different degrees of decompensated cirrhosis, Conclusion The HVPG test is suitable for the diagnosis and evaluation of portal hypertension. The HVPG of patients with different severity of liver cirrhosis can guide the choice of the treatment plan, and the HVPG measurement should also be strictly standardized and quality control.