氯雷他定温敏性凝胶鼻粘膜毒性以及刺激性探究

Nasal Mucosal Toxicity and Irritation of Loratadine Thermosensitive Gel

探究氯雷他定温敏性凝胶剂通过鼻腔给药是否产生鼻黏膜毒性以及刺激性。以鸡胚尿囊膜为模型进行空白凝胶以及给药凝胶对比试验,观察是否产生出血、凝血、溶血等现象;以新西兰白兔为模型观察凝胶剂的刺激性,观察是否出现皮肤红斑、水肿等情况。结果表明,氯雷他定凝胶剂对鸡胚尿囊膜未产生出血、凝血、溶血现象;也不会引起对新西兰白兔刺激反应。

To investigate whether loratadine temperature-sensitive gels produce nasal mucosal toxicity and irritation through nasal administration. To chick embryo allantoic membrane as a model blank gel and gel administration contrast test to observe whether bleeding, coagulation, hemolysis and other phenomena; New Zealand white rabbits as a model to observe the gelling agent irritation, observe the appearance of skin erythema, edema, etc. Loratadinc gel did not produce hemorrhage, coagulation and hemolysis on chick embryo allantoic membrane; nor did it cause irritation to New Zealand white rabbits.