钯催化芳基磺酸酯与亚磷酸酯的交叉偶联反应

Palladium-Catalyzed Cross-Coupling Reaction of Arenesulphonate with Phosphite

有机膦化合物在金属有机化学、配位化学及生物化学中都具有重要的应用价值,而C—P键的偶联反应是合成有机膦化合物的主要方法,也是目前研究的热点.通过使用芳基磺酸酯与亚磷酸酯在金属钯催化下的交叉偶联反应,高效地实现了一系列有机膦化合物的合成,并将该方法运用到了手性N/P配体的合成中.

Organo-phosphorus compounds have important applications in metal-organic chemistry, coordination chemistry and biochemistry. Therefore, the C--P cross-coupling reaction was an important method to prepare organo-phosphorus, which is also a hotspot of current research. Hence, we have studied a kind of cross-coupling reaction between arenesulphonate and phosphites using palladium as the catalyst to synthesize a series of organo-phosphorus compounds efficiently, and the approach was applied to prepare a chiral N/P ligand.