摘要
目的探讨哈尔滨市南岗区甲状腺癌的发病率及其变化趋势,旨在为甲状腺癌的防治提供科学依据。方法甲状腺癌发病数据来源于1992—2013年间哈尔滨市南岗区基于全人群户籍的肿瘤登记系统,人口数据辖区的公安户籍系统。计算甲状腺癌的粗发病率、中国人口标化发病率(ASIRC)、世界人口标化发病率(ASIRW),发病时间变化趋势分析采用Joinpoint回归分析,计算年度变化百分比(APC)和平均年度变化百分比(AAPC)。结果 1992—2013年,哈尔滨市南岗区甲状腺癌平均发病率为5.09/10万,其中男性发病率为2.56/10万,女性发病率为7.64/10万。男性最高发病年龄在45~49岁间,发病率为5.49/10万;女性最高发病年龄在50~54岁间,发病率为17.33/10万。发病率AAPC为12.6%(t=3.9,P<0.01),女性AAPC为11.7%(t=5.1,P<0.01),男性AAPC为13.8%(t=6.4,P<0.01)。结论甲状腺癌的发病率不断增加,特别是2008年后呈现快速上升势态,因此寻找甲状腺癌病因,避免过度诊疗是甲状腺癌的防治方向。
Objective To elucidate the incidence rate and the time trend of thyroid cancer according to the data of cancer registry of Nangang District of Harbin City, and to provide scientific evidence for thyroid cancer prevention and treatment. Methods The thyroid cancer incidence data originated from Nangang District Cancer Registration of Harbin City which based on local population. The population data of each year was collected from census register of public security bureau. Crude incidence rate, age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were calculated. The incidence trend was analyzed by Joinpoint regression model. The annual percent change(APC) and average annual percent change(AAPC) were calculated. Results The average incidence of thyroid cancer was 5.09/10^5(2.56/10^5 for male, 7.64/10^5 for female, respectively) in Nangang District of Harbin City from 1992 to 2013. The highest age-specific incidence occurred in the duration of age 45 to 49 for male(5.49/10^5), and that occurred in the duration of age 50 to 54 for female(17.33/10^5), respectively. The AAPC was 12.6%(t=3.9, P〈0.01), including 11.7% for female(t=5.1, P〈0.01) and 13.8% for male(t=6.4, P〈0.01), respectively. Conclusion With the increase of thyroid cancer incidence, especially it had been sharply rising from 2008, more attention should be paid to searching for thyroid cancer pathogenesis and avoiding over treatment.
作者
陈王洋
孙惠昕
张茂祥
于波
单晓莉
宋冰冰
CHEN Wangyang;SUN Huixin;ZHANG Maoxiang;YU Bo;SHAN Xiaoli;SONG Bingbing(Cancer Prevention Institute, Heilongjiang Academy of Medical Sciences, Harbin 150081, China;Cancer Prevention Institute, Harbin Medical University, Harbin 150081, China;Department of Chronic Disease, Center for Disease Control and Prevention of Nangang District in Harbin City, Harbin 150044, China)
出处
《肿瘤防治研究》
CAS
CSCD
2018年第3期167-170,共4页
Cancer Research on Prevention and Treatment
基金
黑龙江省卫生计生委科研课题(2014-343)
关键词
甲状腺癌
发病率
年度变化百分比
发病趋势
Thyroid cancer
Incidence rate
Annual percent change
Incident trend