摘要
Based on an umpolung strategy, a series of novel full substituted, optically active dihydrothiophenes, which contain several functional groups, such as amine, ester and oxime groups, were obtained via an efficient organocatalytic asymmetric a formal thio[3 ＋ 2]-cyclization of acyclic thioamides with （E）- α-nitrostyrenes.
Based on an umpolung strategy, a series of novel full substituted, optically active dihydrothiophenes, which contain several functional groups, such as amine, ester and oxime groups, were obtained via an efficient organocatalytic asymmetric a formal thio[3 ＋ 2]-cyclization of acyclic thioamides with （E）- α-nitrostyrenes.
基金
provided by National Natural Science Foundation of China(No. 21272214)
