茵栀黄联合二甲双胍治疗非酒精性脂肪肝病临床疗效及对患者血糖、血脂和氧化应激水平的影响

Yinzhihuang Combined with Melbine in Treatment of Nonalcoholic Fatty Liver Disease and the Effect on Blood Glucose and Lipid Level and Oxidative Stress

目的探讨茵栀黄联合二甲双胍治疗非酒精性脂肪肝病(NAFLD)的临床疗效及对患者血糖、血脂和氧化应激水平的影响。方法对我院2015年1月至2017年6月收治的96例NAFLD患者的临床资料进行回顾性分析,根据治疗方式不同将其分为研究组、对照组(各48例),对照组在常规治疗的基础上采用单纯二甲双胍治疗,研究组在常规治疗的基础上采用茵栀黄注射液联合二甲双胍治疗。比较两组治疗疗效及治疗前后丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、空腹血糖(FPG)、餐后2 h血糖(2hPG)、超氧化物歧化酶(SOD)、丙二醛(MDA)及Irisin指标水平。结果研究组治疗总有效率(89.58%)明显高于对照组(70.83%),P<0.05;两组患者治疗前ALT、AST、FPG、2hPG、Irisin、TG、TC、HDL-C、LDL-C、SOD、MDA水平比较均无差异(P>0.05);治疗后两组患者ALT、AST、FPG、2hPG、Irisin、TG、TC、LDL-C、MDA水平均较治疗前下降,且研究组较对照组下降更明显(P<0.05);HDL-C、SOD均较治疗前上升,且研究组较对照组上升更明显(P<0.05)。结论茵栀黄联合二甲双胍治疗NAFLD临床疗效显著,还可有效地改善患者肝功能及血糖、血脂代谢,并具有一定的抗氧化应激作用。

Objective To investigate the clinical efficacy of Yinzhihuang injection combined with melbine in the treatment of nonalcoholic fatty liver disease（ NAFLD） and its effect on blood glucose,lipid levels and oxidative stress.Methods The clinical data of 96 patients with NAFLD treated in our hospital between January 2015 and June 2017 was retrospectively analyzed. According to treatment methods,these patients were divided into the study group and control group（ 48 cases each）. The control group was given melbine plus routine treatment,while the study group received routine treatment and Yinzhihuang injection combined with melbine. The therapeutic effect and levels of ALT,AST,FPG,2 h PG,Irisin,TG,TC,HDL-C,LDL-C,SOD and MDA before and after treatment were compared between the two groups. Results The total effective rate of the study group（ 89.58%）was significantly higher than that of the control group（ 70.83%）（ P〈 0.05）. The levels of ALT,AST,FPG,2 hPG,Irisin,TG,TC,HDL-C,LDL-C,SOD and MDA were not different between the two groups before treatment（ P〉0.05）,but after treatment,the levels of ALT,AST,FPG,2 hPG,Irisin,TG,TC,LDL-C and MDA in the two groups were lower,especially in the study group（ P〈0.05）. Levels of HDL-C and SOD were higher after treatment,especially in the study group（ P〈0.05）. Conclusion The clinical curative effect of Yinzhihuang injection combined with melbine in the treatment of NAFLD is significant by improving the liver function,blood glucose and blood lipid metabolism.