反射式共聚焦显微镜成像的现状与挑战

Current Application and Challenge of In-Vivo Skin Imaging with Reflectance Confocal Microscopy

反射式共聚焦显微镜(RCM)1995年开始在皮肤科应用,可以实现皮肤活体的细胞水平成像。经过20余年的发展,RCM技术在皮肤病筛查、辅助诊断和鉴别诊断,皮肤病和皮肤美容治疗评估等领域得到了广泛应用。本文就RCM技术的优势、应用现状以及应用过程中存在一些问题和挑战进行评述。

The first application of reflectance confoeal microscopy （RCM） was reported in 1995, which provides non-invasive, in-vivo, real time skin imaging with cellular resolution. RCM have been used in Dermatology as a screening tool,providing clues to the derma- tologists for the diagnosis and differential diagnosis of skin disorders,and it was also reported to follow up and evaluate different treatment modalities in skin diseases. We review the current application of RCM together with problems and challenges encoun- tered during the clinical practice.