摘要
全膝关节置换术(total knee arthroplasty,TKA)是当今骨科关节组常见的手术,近年来由于人们对膝关节骨关节炎的重视,以及对生活质量要求的提高,行人工TKA的患者日益增多,随着手术技术的提高,手术治疗效果也越来越好,但是术后发生深静脉血栓(deep vein thrombosis,DVT)成为影响手术效果的重要危险因素。
Anticoagulant drugs can prevent deep vein thrombosis and related complications after total knee arthroplasty. Traditional anticoagulant drugs ( unfractionated heparin, low molecular weight heparin, warfarin, etc. ) take preventive effects. At present, some new oral anticoagulants ( rivaroxaban, apixababan ) have been widely used in clinical practice to provide patients with a safer, more convenient and effective option for the prevention of postoperative venous thrombosis. This review focuses on the advantages and disadvantages of traditional anticoagulants such as low molecular weight heparin, vitamin K antagonists, and novel oral anticoagulants rivaroxaban, apixaban. Clinical comparison of traditional anticoagulant drugs with novel oral anticoagulants is taken to provide a reference.
作者
柏正文
黄江
安帅
李征
冯明利
曹光磊
沈惠良
BAI Zheng-wen;HUANG Jiang;AN Shuai;LI Zheng;FENG Ming-li;CAO Guang-lei;SHEN Hui-liang(Department of Orthopedics, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China)
出处
《中国骨与关节杂志》
CAS
2018年第4期292-296,共5页
Chinese Journal of Bone and Joint
基金
北京市优秀人才青年骨干资助项目(2015000020124G116)
关键词
静脉血栓形成
抗凝血酶蛋白类
手术后并发症
关节成形术
置换
膝
综述
Venous thrombosis
Antithrombin proteins
Postoperative complications
Arthroplasty, replacement, knee
Review