摘要
转化生长因子-β(transforming growth factor-β,TGF-β)超家族由多种细胞因子组成,主要的配体分为TGF-β和骨形成蛋白(bone morphogenetic protein,BMPs)两类。近年来发现,TGF-β和BMPs刺激调节肺血管平滑肌的增殖,相互之间存在拮抗,表现为Smads依赖和Smads不依赖2种方式;个体基因的变异可能导致TGF-β和BMPs对肺血管平滑肌细胞增殖产生不同甚至相反的效应。本文就转化生长因子-β及骨形成蛋白通路调节肺动脉血管平滑肌细胞异常增殖进行综述。
The transforming growth factor-β（TGF-β） superfamily is composed of many cytokines,mainly including of TGF-βs and bone morphogenetic proteins （BMPs）. Recently, antagonism effect between TGF-βs and BMPs on proliferation in pulmonary artery smooth muscle cells is showed. Furthermore,individual genes variation might cause to different, even opposite effects of TGF-βs or BMPs on the proliferation. This article reviewed the regulation of TGF-β and BMPs signal pathways on abnormal proliferation in pul- monary artery smooth muscle cells.
作者
任周新
李建生
余海滨
梅晓峰
刘学芳
沈俊岭
Ren Zhouxin;Li Jiansheng;Yu Haibin;Mei X iaofe ng;L iu Xuefang;She n Junling(Henan University of Chinese Medicine, Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment ＆ Chinese Medicine Development of Henan Province;Department of Heart Center, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2018年第3期307-310,共4页
Journal of Chongqing Medical University
基金
国家自然科学基金资助项目(编号:81473650)
国家中医临床研究基地业务建设第二批科研专项课题资助项目(编号:JDZX2015156)
关键词
肺动脉高压
转化生长因子-Β
骨形成蛋白
平滑肌细胞增殖
pulmonary artery hypertension
transforming growth factor -β
bone morphogenetic protein
proliferation of pulmonaryartery smooth muscle cells
