中药治疗成人斯蒂尔病的用药规律研究

Study of Administration Rule of Chinese Medicine for Adult Onset Still's Disease

目的:探讨分析中药治疗成人斯蒂尔病(AOSD)的用药规律。方法:检索中国期刊全文数据库(CNKI)、维普中文科技期刊(VIP)、中国学术期刊数据库(万方数据),通过整理相关文献,建立数据库,并用统计软件对中药治疗AOSD的用药规律进行分析。结果:47篇治疗AOSD的文献中,涉及中药229味,累计使用1 153次;单味药中使用频率较高的前5味药分别是甘草(3.04%)、知母(2.95%)、牡丹皮(2.60%)、黄芩(2.60%)、生地黄(2.60%);按功效归类则清热药(35.76%)所占比例最大,其次为补虚药(18.48%),解表药(9.38%)、利湿药(9.11%)和祛风湿药(5.72%)。清热药以清热解毒和清热凉血药为主;补虚药以补气和补阴药为主。结论:AOSD的治疗有其自身的特点,用药以清热药解毒凉血、补虚药益气养阴为主,兼以解表药、利湿药和祛风湿药等共同治疗。

Objective：To explore and analyze the administration rule of Chinese medicine for adult onset still＇s disease（AOSD）. Methods： China national knowledge internet（CNKI）, VIP Journal Integration Platform（VIP） and China Science Periodical Database（Wanfang data） were searched to sort out related literatures and establish a database. The administration rule of Chinese medicine for AOSD was analyzed via statistical software. Results：Among 47 pieces of literature for AOSD,229 kinds of Chinese medicine and 1153 times of administration frequency were found. The top 5 medications applied in single medicine in terms of administration frequency were radix glycyrrhiza（3.04%）,rhizoma anemarrhenae（2.95%）, cortex moutan（2.60%）, radix scutellariae（2.60%） and dried radix rehmanniae（2.60%）. In terms of efficiency,heat-clearing medicine（35.76%） accounted for the biggest frequency, followed by tonifying medicine（18.48%）, exterior-releasing medicine（9.38%）, dampness-draining medicine（9.11%）,and wind-dampness-dispelling medicine（5.72%）. Heat-clearing medicine mainly included heat-clearing and detoxifying medicine as well as heat-clearing and blood-cooling medicine. Tonifying medicine mainly included qi-tonifying medicine and yin-tonifying medicine. Conclusion：Treatment for AOSD has its own characteristics. The medication mainly focuses on heat-clearing medicine to detoxify and cool blood,as well as tonifying medicine to tonify qi and nourish yin,which combined with exterior-releasing medicine, dampness-draining medicine,wind-dampness-dispelling medicine and other medicine.