杏苏二陈汤联合西医疗法治疗风寒型慢性支气管炎急性发作期疗效观察

Clinical Observation of Xingsu Erchen Tang Combined with Western Medicine Therapy for Chronic Bronchitis of Wind-Cold Type in Acute Attack Stage

目的:观察杏苏二陈汤联合西医疗法治疗风寒型慢性支气管炎急性发作期患者的临床疗效。方法:纳入70例风寒型慢性支气管炎急性发作期患者进行临床研究,按入院先后顺序分为观察组和常规组各35例,2组均予常规及对症治疗,常规组予沐舒坦治疗,观察组加用杏苏二陈汤治疗,2组均治疗20天。观察2组患者治疗前后中医证候评分、肺功能指标[第1秒用力呼气容积(FEV_1)、第1秒用力呼气容积占预计值百分比(FEV_1%)、用力肺活量(FVC)、第1秒用力呼气容积占用力肺活量比值(FEV_1/FVC)的变化及对比治疗效果。结果:治疗后,常规组总有效率为68.57%,观察组总有效率为94.29%,2组比较,差异有统计学意义(P<0.05)。2组各项中医证候(咳嗽、咯痰、喘息、痰色质、鼻塞、恶寒、发热)评分及总积分均较治疗前降低(P<0.05),观察组各项中医证候评分及总积分均低于常规组(P<0.05)。2组各项肺功能指标值[FEV_1、FEV_1%、FVC、FEV_1/FVC]均较治疗前上升(P<0.05),观察组各项肺功能指标值均高于常规组(P<0.05)。结论:杏苏二陈汤联合西医疗法治疗风寒型慢性支气管炎急性发作期患者,可有效缓解临床症状,改善肺功能,提高临床疗效。

Objective：To observe the clinical effect of Xingsu Erchen tang combined with western medicine therapy for chronic bronchitis of wind-cold type in acute attack stage. Methods：Enrolled 70 cases of patients with chronic bronchitis of wind-cold type in acute attack stage into the clinical research,and divided them into the observation group and the routine treatment group randomly according to the sequence of admission,35 cases in each group. Both groups received the routine and symptomatic treatment,as the routine treatment group received ambroxol while the observation group additionally received Xingsu Erchen tang. The treatment of both groups lasted for twenty days. Observed the changes of Chinese medicine syndrome scores and indexes of pulmonary function [forced expiratory volume in 1 second（FEV1）,the percentage of forced expiratory volume in 1 second in the expected value（FEV1%）,forced vital capacity（FVC）,the ratio of forced expiratory volume in 1-second to forced vital capacity（FEV1/FVC）] of both groups before and after treatment,and compared its clinical effect.Results：After treatment,the total effective rate was 68.57% in the routine treatment group and 94.29% in the observation group,difference being significant（P〈0.05）. Each scores of Chinese medicine syndrome（cough,expectoration,wheezing,color and texture of phlegm,nasal obstruction,aversion to cold,fever） and the total score in both groups were lower than those before treatment（P〈0.05）, and each scores of Chinese medicine syndrome as well as the total score in the observation group were lower than those in the routine treatment group（P〈0.05）. Each index of pulmonary function [FEV1,FEV1%,FVC,FEV1/FVC] in both groups was higher than that before treatment（P〈0.05）,and each index of pulmonary function in the observation group was higher than that in the routine treatment group（P〈0.05）. Conclusion：Xingsu Erchen tang combined with western medicine therapy for chronic bronchitis of wind-cold type in acute attack stage can effectively release clinical symptoms,improve pulmonary function and enhance clinical effect.